Jurnal Ilmiah Ibnu Sina

FORMULASI DAN UJI AKTIVITAS GEL ANTIJERAWAT FRAKSI N-HEKSAN DAUN KERSEN (Muntingia calaburaL.) TERHADAP BAKTERI Propionibacterium acnes

Saparuddin Latu — 2024-03-31

ABSTRACT

Cherry leaves contain many compounds, namely flavonoids, tannins, saponins, phenolics, steroids, and alkaloids. One of the compounds that act as an antibacterial is the flavonoid compound. One of the uses of cherry leaves is anti-acne. Acne is a chronic inflammatory disease of the pilosebaceous glands. One of the bacteria that causes acne is Propionibacterium acnes bacteria. Preparations that can be made for anti-acne are gel preparations. This study aims to determine whether the n-hexane fraction of cherry leaf (Muntingia calabura L.) can be made into anti-acne gel preparations and to find out at what concentration the n-hexane fraction of cherry leaf (Muntingia calabura L.) in anti-acne gel preparations can provide antioxidant activity. inhibiting the growth of Propionibacterium acnes bacteria. This research method is true experimental by making an anti-acne gel preparation of the n-hexane fraction of cherry leaves (Muntingia calabura L.) with various concentrations of 2.5%, 5%, 7.5% and testing the activity of the preparation against Propionibacterium acnes using the well method. so that. The results of the gel preparation formula showed that there were significant differences before and after the cycling test in both organoleptic, homogeneity, pH, viscosity, spreadability and adhesion tests. The activity test results obtained were that the largest inhibition zone was the concentration of 2.5%, namely 11.7 mm, which was in the strong category, while the 5% concentration, which was 13.4 mm, was in the strong category, and the concentration of 7.5%, which was 15.0 mm, was included in the category strong.

PROFIL DISOLUSI TABLET LEPAS LAMBAT KALIUM DIKLOFENAK MENGGUNAKAN PATI PREGELATINASI TALAS PRATAMA (Colocasia esculenta (L). Schott var. Pratama)

Desy Nawangsari — 2024-03-31

Starch is one of the commonly used excipients in tablet preparations. Natural starch has limitations in the form of poor flow rate and compressibility, so it is not suitable for use in the manufacture of tablets by direct compression. One source of plants that produce starch and has not been widely developed is (Colocasia esculenta (L). Schott var. Pratama). The purpose of this study was to modify (Colocasia esculenta (L). Schott var. Pratama) starch by gelatinization used in diclofenac potassium slow-release tablets. This research is a type of laboratory experimental research that begins with the isolation of starch from taro tubers, modification of starch by pregelatinization, manufacture of diclofenac potassium slow release tablet press mass, evaluation of physical properties and finished tablet dissolution tests. The results of the printing mass test showed that the use of (Colocasia esculenta (L). Schott var. Pratama) pregelatinated starch matrix had good flowability. The results of the tablet test showed that the average tablet weight was 209 ± 3.40 mg, the diameter and thickness were 7.69 ± 0.02 and 2.82 ± 0.01 mm respectively, the hardness was 7.00 ± 0.35 kg, the friability was 0. 73 ± 0.27 % and disintegration time 65.33 ± 2.52 minutes and the dissolution results showed that within 8 hours the potassium diclofenac sustained release tablet dissolved 60.20%. Based on the physical properties and dissolution tests performed, it can be concluded that the use of pregelatinated modified starch as a matrix in diclofenac potassium slow-release tablets fulfills the specified test parameters.

EVALUASI PENGELOLAAN SEDIAAN FARMASI DI GUDANG INSTALASI FARMASI RSUD DR. DRAJAT PRAWIRANEGARA SERANG-BANTEN TAHUN 2022

Yusransyah Yusransyah — 2024-03-31

Pharmaceutical supply management is a series of sequential actions that begin with the procurement of drugs, the act of receiving drugs, and the process of storing drugs. This study aims to evaluate the suitability of pharmaceutical preparation management process at the Pharmacy Installation, Regional General Hospital dr. Drajat Prawiranegara in 2022 according to the provisions of the Regulation of the Minister of Health of the Republic of Indonesia Number 72 of 2016. The research method is explained quantitatively through selecting information, carried out in observation as an assessment and analysis of suitability. After the evaluation, aspects of the procurement process were identified that met the standards, including the high frequency of procurement per drug item (48 times per year), complete orders or invoices, and no late payments from the hospital. The aspect of the receiving process has also met the standards. That is, all drug orders are by the goods received. The storage process has met the standards, namely all goods according to the stock card, while the Turn Over Ratio (TOR) aspect has not met the standards with a value of 3.91 times. The warehouse management system uses First In First Out (FIFO) and First Expired First Out (FEFO). The percentage of damaged or expired drugs and the percentage of non-spinning stock is 0%. The conclusion of this research is the process of procuring and receiving drugs at IFRS dr. Dradjat Prawiranegara Serang has followed the guidelines, but in the TOR aspect it has not met the standards.

FORMULASI DAN UJI IN VITRO NILAI SPF KRIM TABIR SURYA EKSTRAK KULIT BUAH NANAS MADU (Anana comosus L. Merr)

Wimzy Rizqy Prabhata — 2024-03-31

Excessive UV exposure from sun causes negative impacts on the skin. Honey pineapple peel (Anana comosus L. Merr) is known to contain flavonoid and tannin that absorb UV light. This study reports the activity of sunscreen in cream preparations of 96% ethanolic extract of honey pineapple peel along with its physical characteristics and stability test results. Honey pineapple peel was soxhleted using 96% ethanol. The extract was then formulated into a cream using various concentrations of cream base: stearic acid (8-12%) and triethanolamine (2-4%) generating three formulas. The cream was then tested for its physical characteristics, physical stability, and sunscreen activity. The SPF value of extract at concentrations of 10%, 20%, and 30% respectively were 28.38; 31.05; and 35.12. The physical characteristics of the cream were brown in color, semisolid in shape, have a distinctive smell, homogeneous; with pH value, adhesion capability and spreadability that meet the cream requirements. Of the three formulas, formula I has the best pH stability, adhesion capability and spreadability. The results of SPF value of each cream formula: F1 (34.54); F2 (34.35) and F3 (34.27). This study demonstrated that the 96% ethanolic extract of honey pineapple peel can be formulated into cream dosage form and has a good sunscreen activity.

ASESMEN RISIKO PERDARAHAN SEKELOMPOK PASIEN FIBRILASI ATRIUM PENERIMA WARFARIN BERDASARKAN NILAI HAS-BLED DI RS ABC GIANYAR

Putu Dian Marani Kurnianta — 2024-03-31

In the management of atrial fibrillation (AF) preventing risk of stroke, warfarin may be prescribed. Warfarin’s narrow therapeutic index encourages the importance of regular monitoring during therapy to avoid the risk of bleeding. This study aimed to describe the risk of bleeding in a group of patients with AF receiving warfarin based on HAS-BLED score assessment at ABC Hospital Gianyar, Bali. A descriptive-observational study was conducted under retrospective case study approach involving outpatient’s data at mentioned hospital. This study included all patients with AF receiving warfarin based on visit history during January 2022-May 2023. Risk of bleeding documentation addressed the HAS-BLED assessment which then were illustrated into tables and diagram according to patients’ profile. From a total of eight eligible patients, five patients (62.5%) had moderate-risk of bleeding (score 1-2) and the rest were in the low-risk category (score 0). Advanced age >65 y.o. (50.00%), use of specified drugs (25.00%), and high INR values had contributed to the findings of moderate-risk based on stratification category. Despite the absence of high-risk category, therapeutic monitoring is necessary focusing on modifiable risk factors. The limited number of samples and several laboratory parameters may suggest for the advancement of clinical practice and further research.

SENYAWA FITOKIMIA DAN AKTIVITAS ANTI COVID STUDI IN SILICO EKSTRAK CABE JAWA (Piper retrofractum Vahl)

Umarudin Umarudin — 2024-03-31

Javanese chili has the potential to develop, one of which is that it contains phytochemical compounds and essential oils, which can act as antioxidants in preventing COVID-19, so it is necessary to utilize the natural potential in Indonesia, namely Javanese chili. This research aims to determine the phytochemical screening and anti-covid activity of an in silico study of Javanese chili extract. This research method carried out phytochemical screening of ethanol extracts, tested for alkaloids, flavonoids, tannins, saponins, and terpenoids, tests for determining levels of piperine, essential oils, and cavitsin, as well as in silico studies with piperine ligands with RdRP and ACE2 receptors docked with Hex.8.0.0 and visualized with discovery studio. This research shows that the phytochemical screening results of Javanese chili fruit extract are positive for containing alkaloids, flavonoids, tannins, saponins, terpenoids, piperine 3.36%. This research concludes that in silico, the Javanese chili piperine compound can bind to the active site of ACE Sarcov 2 through RdRP inhibition.

UJI AKTIVITAS ANTI TUBERKULOSIS H37RV EKSTRAK DAN FRAKSI TANAMAN MERBAU (Intsia bijuga)

Ayik Rosita Puspaningtyas — 2024-03-31

Tuberculosis (TB) is recognized as one of the top ten potentially fatal diseases. TB is caused by the bacterium Mycobacterium tuberculosis, which attacks the lungs. Indonesia has a variety of plants that can potentially serve as a treatment, one of which is the merbau plant (Intsia bijuga). The purpose of this study was to determine the anti-tuberculosis activity of extracts and fractions of merbau stem bark against Mycobacterium tuberculosis H27Rv bacteria based on IC₅₀ values. Merbau bark was extracted using maceration method using methanol solvent. Then fractionated using n-hexane, dichloromethane (DCM) and ethyl acetate solvents. Next was phytochemical screening test using KLT method. In vitro anti-tuberculosis activity test using resazurin colorimetric method with concentrations of 25, 100, 500, and 1000 µg/mL. The results of the in vitro anti-tuberculosis test showed that the n-hexane fraction had the smallest IC50 of the extracts and other fractions with a result of 2,920 µg/mL, which indicates that it has the best activity as an anti-tuberculosis agent. Screening results from the n-hexane fraction showed positive for alkaloid and flavonoid compounds.

UJI AKTIVITAS TABIR SURYA EKSTRAK DAN LOTION KUNYIT (Curcuma domestica Val.) SECARA INVITRO MENGGUNAKAN SPEKTROFOTOMETER UV-VIS

Muhammad Alfian — 2024-03-31

Excessive UV B radiation can lead to premature skin aging, but research suggests that turmeric (Curcuma domestica Val.) may have antioxidant compounds that could serve as a sunscreen. To investigate, the researchers tested turmeric extracts and lotions in vitro using a UV-Vis spectrophotometer. They extracted turmeric by maceration with 70% ethanol to obtain a thick extract, then evaluated the physical characteristics of turmeric lotion preparations including organoleptics, spreadability, adhesion, pH, SPF values (using the Mansur method), and Erythema Transmission Percentage (%T) in vitro using a UV-Vis spectrophotometer with absorbance wavelengths of 290-320 nm. The results showed that F1 to F5 turmeric lotion preparations were semi-solid, brownish yellow, fragrant, with spreadability above 7 cm, adhesion less than 1 second, and pH below 8. The highest SPF value of turmeric extract was at a concentration of 500 mg with SPF 46, while the highest SPF of turmeric lotion was F5 with SPF 15. All turmeric extracts are categorized as sunblock, while F5 lotion is also sunblock and F1 to F4 lotions are fast-tanning. Although the SPF value decreases when turmeric extract is made into a lotion, it still has sunscreen potential.

PENGARUH METODE MICROWAVE-ASSISTED EXTRACTION (MAE) DENGAN PELARUT NATURAL DEEP EUTECTIC SOLVENT (NADES) EKSTRAK DAUN MANGGA GEDONG TERHADAP KADAR TOTAL FLAVONOID DAN AKTIVITAS ANTIOKSIDAN

Fadzil Latifah — 2024-03-31

Antioxidant activity with flavonoids has a strong relationship because it is influenced by the functional groups attached to the main structure. This study aims to determine the effect of solvents and extraction methods used on total flavonoid levels and antioxidant activity of gedong mango leaf extract. Gedong manggo was extracted using teh MAE-NADES combination method (sodium acetate and lactic acid solvents 1:3 in distilled water until temperature reached 70 ). Gedong mango were extracted in terms of temperature and time (80 :20', 80 :10', 60 :20', 60 :10'). Next, the value of total flavonoid content and antioxidant activity was determined for the extract. The results showed that gedong mango leaf extract had high total flavonoid content values, with respective values of 80 :20' 6.5994%, 80 :10' 5.5504%, 60 :20' 5.0890%, and 60 :10' 3.8902%. In addition, gedong mango leaf extract has antioxidant activity, with IC₅₀value of 80 :20 ' 21.666 ppm, 80 :10' 39.734 ppm , 60 :20' 61.687 ppm, and 60 :10' 135.487 ppm. From the results of the study it can be concluded that the MAE method using NADES solvent has values for total flavonoid levels and antioxidant activity. The best gedong mango leaf extract was at temperature and time of 80:20 '. Where the total value of flavonoids is directly proportional to the antioxidant activity, the higher the value of the flavonoid compounds produced, the higher the antioxidant activity.

POTENSI SALEP EKSTRAK ETIL ASETAT Jatropha multifida L. SEBAGAI AGEN PENYEMBUHAN LUKA

Akhirul Kahfi Syam — 2024-03-31

Jarak tintir (Jatropha multifida L.) umumnya terkenal sebagai tanaman hias yang berasal dari suku Euphorbiaceae. Masyarakat secara empiris memanfaatkan bagian getahnya sebagai obat luka. Telah dilakukan penelitian mengenai suku Euphorbiaceae memiliki aktivitas sebagai antioksidan pada ekstrak etil asetat dengan nilai IC₅₀ < 50 ug/mL. Tujuan penelitian ini untuk melihat potensi metabolit sekunder pada ekstrak etil asetat yang berpotensi sebagai antioksidan untuk dikembangkan sebagai kosmedika penyembuhan luka. Ekstraksi simplisia batang jarak tintir dilakukan menggunakan Refluks dengan pelarut etil asetat. Aktivitas antioksidan yang dinyatakan dalam nilai IC₅₀ diuji menggunakan metode peredaman radikal bebas DPPH. Formulasi sediaan salep menggunakan basis vaselin album dan ekstrak etil asetat dengan konsentrasi 5,5% dan 11%. Potensi aktivitas penyembuhan luka dari ekstrak etil asetat dilakukan dengan metode telaah jurnal. Hasil uji aktivitas antioksidan ekstrak etil asetat memberikan nilai IC₅₀ 110,4 µg/mL. Formulasi sediaan salep ekstrak etil asetat batang Jarak tintir dengan konsentrasi 5,5% dan 11% memenuhi persyaratan uji evaluasi sediaan salep yang baik. Hasil telaah pustaka, metabolit sekunder yang memiliki potensi aktivitas antioksidan juga memiliki potensi sebagai agen penyembuhan luka dengan berbagai mekanisme penyembuhan dan metabolit sekunder yang bertanggung jawab sebagai agen penyembuhan luka antara lain alkaloid, flavonoid, tanin dan saponin.

FORMULASI DAN EVALUASI PRODUK INOVASI BALSEM SINDRONG JANGKEP DENGAN PENAMBAHAN MINYAK ATSIRI NILAM (Pogostemon Cablin Benth)

Putu Lakustini Cahyaningrum — 2024-03-31

The complexity of infectious and non-communicable diseases has led to the development of traditional medicine. This is mediated by safety, side effects, and relatively cheaper prices. Medicinal plants have been developed in the form of sindrong jangkep balm products combined with patchouli essential oil (Pogostemon cablin Benth). The purpose of this study was to determine the formulation and evaluation of sindrong jangkep balm products combined with patchouli essential oil. Experimental research design with a completely randomized design. Three concentrations of sindrong jangkep were formulated, 1:1, 2:2, and 4:4, and analyzed for efficacy. The results of the physical quality evaluation of sindrong jangkep balm with the addition of patchouli essential oil as a whole have a distinctive odor of sindrong jangkep, pale yellow to brownish color, semi-solid texture, all homogeneous, have a spreadability between 5.50-5.85 cm with a stickiness of 3-5 seconds, and viscosity, between 56,000-63,000 cP. Chemical quality obtained pH for FI 6.74 ± 0.142 combination of sindrong jangkep oil and patchouli essential oil ratio 1:1; FII with pH 6.29 ± 0.075 ratio 2:2, and FIII with pH 5.32 ± 0.015 ratio 4:4 has met the requirements and is safe for skin preparations. Sindrong jangkep balm supplemented with essential oil fulfilled the prerequisites for balm preparation and is worth developing in the future.

DETERMINATION OF LEAD AND CADMIUM LEVELS IN CANNED SARDINES USING ATOMIC ABSORPTION SPECTROPHOTOMETRY

Citra Hayu Adi Makayasa — 2024-04-01

Canned sardines are hermetically sealed and processed to ensure sterility and provide practical convenience in processing fish. Contact between food and canned causes the migration of metal elements into them. The high content of metals, lead (Pb) and cadmium (Cd) in canned food has a negative impact on health. This study aims to determine both metal levels in canned sardines and to identify the fulfillment of several validation parameters against Atomic Absorption Spectrophotometry (AAS). Sardines were weighed, digested with concentrated HNO₃:30% H₂O₂ and analyzed using AAS. Pb and Cd levels in canned sardines were not detected by AAS. This method meets the requirements of validation parameters, Pb and Cd, selective on specific wavelengths 283.3 nm and 228.3 nm, the standard curve is linear with a relative process standard deviation (Vx₀) value < 5% and the Xp value is smaller than the lowest concentration in the standard curve, 0.69 mg/l and 2.31 mg/l are the results of the Limit of Detection (LOD) and Limit of Quantitation (LOQ) values of Pb while Cd 0.20 mg/l and 0.67 mg/l, 80-120% is %recovery of accurate parameters and a relative standard deviation (RSD) value < 2% is precision parameters. The SSA method can be used to quantitatively determine Pb and Cd levels in canned sardines.

STUDI KUALITATIF PERSEPSI APOTEKER DAN KADER KESEHATAN DALAM PEMANTAUAN OBAT ANTI TUBERKULOSIS DI PUSKESMAS MLATI II SLEMAN

Ulfa Mustofa Nurfadilasari — 2024-03-31

Background: Long-term treatment of tuberculosis can cause side effects that cause concern for patients. The side effects experienced by patients have an impact on treatment compliance and drug withdrawal. Efforts to control drug withdrawal require the role of pharmacists and cadres in monitoring treatment. Objective: to explore the perception of understanding and actions of pharmacists and cadres in monitoring anti-tuberculosis drugs. Method: This study is qualitative study with a case study approach. Participants selection using purposive sampling namely pharmacists, cadres and TB program holders who are involved in monitoring TB treatment. The number of participants was six people. Results: interview transcripts were analyzed thematically using software QSR NVivo 12. We categorized into three themes : drug side effects, medication adherence, and treatment success. Conclusion: pharmacists' understanding and actions in monitoring TB treatment are good. While the cadres' understanding and actions regarding the side effects of drugs are not good enough, the importance of compliance with taking medication and the success of treatment is good

ANALISIS BIAYA DAN RASIONALITAS TERAPI PARU OBSTRUKTIF KRONIK DI RSU ANWAR MEDIKA SIDOARJO

Amelia Lorensia — 2024-03-31

COPD is the main cause of death, and is currently the fifth cause of death in the world. COPD patients experience decreased capacity for quality of life, physical disability and increased costs of living. In COPD patients, the use of more than one drug therapy and long-term use can carry the risk of drug-related problems. The aim is to analyze the costs and rationality of treating COPD exacerbations. The research design was retrospective to determine the costs and description of therapy for COPD patients at RSU Anwar Medika Sidoarjo. The variables are real costs, INA-CBGs rates, severity and treatment therapy. The research sample was inpatients with BPJS insurance who were diagnosed with COPD attacks at RSU Anwar Medika Sidoarjo for January 2019-December 2021, using the total sampling method. The data collection by observing research materials including medical records. Data analysis is descriptive for data analysis and the incidence of drug-related problems (MTO), and the Mann-Whitney test to determine significant differences between real hospital costs and INA CBG'S inpatient rates. The number of respondents involved was 81 people. The highest components of direct costs incurred by COPD patients during hospitalization are hotel room costs and the cost of consumable medical materials. There was no difference in real costs compared to the rates INA-CBG's (p=0.158). The total incidence of MTO that occurred was 83 cases consisting of inappropriate drug selection (19.27%), drugs without indications (66.26%), inappropriate drug combinations (4.81%), indications without drugs (2 .40%), too many drugs for same indication (7.22%).

POTENSI HIDROSOL SEREH WANGI SEBAGAI SPF (SUN PROTECTION FACTOR) DALAM SEDIAAN LOTION MIKROEMULGEL

Ester Dwi Antari — 2024-03-31

The inclusion of sunscreen in cosmetic products is widely used globally in the cosmetics industry as it ensures adequate protection against harmful UV rays. This sunscreen product can be packaged into emulsion, cream, gel, and lotion. Cymbopogon nardus hydrosol is a by-product of the distillation of essential oils. This hydrosol is often unused and is simply thrown away, causing new environmental problems. Cymbopogon nardus hydrosol still has the properties of Cymbopogon nardus essential oil as an antioxidant with an IC50 value of 9,322 ppm which is included in the very strong antioxidant category.

Cymbopogon nardus hydrosol was made using the water distillation method, then microemulgel lotion was made and physical tests were carried out on the microemulgel lotion. Hydrosol and microemulgel lotion were measured for SPF values.

The research results showed that Cymbopogon nardus hydrosol and Cymbopogon nardus microemulgel lotion preparations had SPF values in the ultra category. The higher the SPF value, the better it will protect the skin from the bad effects of UV radiation, one of which is skin cancer. Antioxidants are able to reduce superoxide through the formation of hydroperoxide intermediates so that they can prevent biomolecular damage by free radicals. The microemulgel preparation was stable in the Cycling stability test.

PENINGKATKAN PEMAHAMAN KELOMPOK TANI TERHADAP PENGOBATAN TUBERCULOSIS DAN PENCEGAHANNYA MELALUI FOCUS GROUP DISCUSSION

Abdul Rahem — 2024-03-31

Tuberculosis was a cause of global morbidity and mortality. Sumenep Regency has a high number of TBC cases, namely in 2017  were 1,627 people and 1,709 people in 2018. The difficulty in overcoming them is mainly due to the public and drug managers' understanding regarding drug side effects. Therefore, it is necessary to increase their literacy regarding this matter. This research aims to analyze the influence of Focus Group Discussions on farmer group members' understanding of the treatment and prevention of tuberculosis. It also analyzes the understanding of community health center drug managers regarding the side effects of TBC drugs and how to deal with them. A quasi-experimental design, with a pretest â€“ posttest design, was carried out on 49 members of the Bungbungan village farmer group and 39 community health center drug managers in Sumenep. The results showed that the farmer group understanding scores before and after the intervention were as follows: 6.02Â±1.19 and 6.69Â±1.46. for drug managers were 14.67Â±2.41 and 18.36Â±1.65. Conclusion The Focus Group Discussion had an impact on increasing understanding of the treatment and prevention of tuberculosis for farmer groups, and for community health center drug managers it had an impact on understanding the side effects of TBC drugs and how to deal with them.

ANALISIS BIAYA MEDIS LANGSUNG PASIEN BPJS BRONKOPNEUMONIA BALITA DI RAWAT INAP RUMAH SAKIT ISLAM SURABAYA ACHMAD YANI

Dewanti Wardhani — 2024-03-31

Bronchopneumonia is a type of disease that attacks the lungs, often occurring in the bronchi and alveoli, which is caused by viruses, bacteria or fungi. Bronchopneumonia is the most frequently diagnosed infectious disease at the Surabaya Achmad Yani Islamic Hospital in 2022. The aim of the research is to determine the real direct medical costs of toddler bronchopneumonia and the components that make up real direct medical costs. The research uses an observational research design. Data collection was carried out in October 2023 by reviewing medical record data of patients who met the inclusion criteria during the period January 2023-March 2023. The research subjects consisted of 172 patients. The research results show that the real direct medical costs for toddler bronchopneumonia based on the perspective of the Surabaya Achmad Yani Islamic Hospital during the period January 2023-March 2023 are IDR. 463,267,781 with an average cost per patient of Rp. 2,693,417. The largest component of real direct medical costs is the component of use of hospital facilities at 34.87% and the component of costs for medicines and consumable medical materials at 34.06%. Cost analysis is very important so that patient treatment costs become more effective and efficient.

EFEKTIVITAS SEDIAAN PATCH EKSTRAK DAUN SIRIH MERAH (Piper crocatum) SEBAGAI PENYEMBUHAN LUKA BAKAR DERAJAT II SECARA IN VIVO

Rosa Amelia — 2024-03-31

Burns are a health problem that is often faced in Indonesia with a high incidence rate. One approach that has been taken in treating burns is using natural medicines. The red betel plant (Piper crocatum) has the potential as an anti-inflammatory and wound-healing agent. Transdermal patch preparations are an alternative form of drug dosage with various advantages. This study aims to evaluate the effectiveness of red betel leaf extract patches in healing second-degree burns in vivo. Patch preparations were made with several different formulations, and evaluations were carried out on the patch preparations. The treatment groups were carried out on male white rats of the Wistar strain, which were divided into four groups of red betel leaf extract patch formulations. Treatment was carried out for 14 days. Several parameters to assess effectiveness for healing second-degree burns include moisture, color, and scab. The results of the LSD posthoc test showed that there was a difference in the mean between treatment groups with significant healing of burn wounds in mice (p-value < 0.05). The F4 red betel leaf extract group (30%) showed the highest healing value of 50.37%. Red betel leaf extract (Piper crocatum) is effective in healing second-degree burns in vivo.

IDENTIFIKASI TANAMAN OBAT TRADISIONAL YANG DIPERGUNAKAN SUKU ANAK DALAM DESA DWI KARYA BAKTI, KABUPATEN BUNGO, PROVINSI JAMBI

Dwi Noerjoedianto — 2024-03-31

One of the local wisdoms in Jambi Province is the Anak Dalam Tribe (SAD), which is known for its expertise in making traditional medicinal concoctions. This study aim was to identify traditional medicinal plants used by SAD in Dwi Karya Bakti Village, Bungo Regency, Jambi Province. Data collection from September to November 2023 using in-depth interviews, observation and documentation of

medicinal plants, how to mix them and the types of diseases treated. Representative sampling of medicinal plants from the informants' routine locations for collecting medicinal plants. The results of this research grouped medicinal herbs into 5 groups of medicinal plants commonly used by the SAD community in Dwi Karya Bakti Village, namely groups for cough and sore throat medicines, diarrhea medicines, diseases in mothers and children, external medicines (boils, canker sores). and aches) as well as fever medication. The parts of the plant that most used were the leaves (38%), the least used were the flowers (5%) and roots (5%). The processing that most often done was used directly (73.50%) without boiling or burning, and the least processing method was boiling (10.5%). The most common ways of use were drinking (31.5%) and applying topically (31.5%), while the least ways by dropping it, making it into a necklace, tying it or bathing it at 5% each.

FORMULASI GEL HAND SANITIZER EKSTRAK DAUN BELIMBING WULUH (Averrhoa bilimbi L.)

Tria Prayoga — 2024-03-31

In an effort to counteract skin irritation due to repeated use of alcohol-based hand sanitizers, there is increasing interest in non-alcoholic alternatives incorporating natural antibacterial ingredients. This study focuses on developing a hand sanitizer gel utilizing ethanol extract from Averrhoa bilimbi L. leaves as an antibacterial agent, evaluating the effect of Carbopol 940 concentration on product characteristics. The aimed to develop a hand sanitizer gel that leverages the antibacterial properties of Averrhoa bilimbi L. leaf ethanol extract, by testing the effects of different Carbopol 940 concentrations (0.4%, 0.5%, and 0.6%) on product characteristics. The methods used included organoleptic, homogeneity, viscosity, and pH tests, with data processing using one-way ANOVA and Tukey HSD. Tye results of Organoleptic and homogeneity testing of all gel formulas on a weekly basis revealed consistent characteristics, with a yellow-brown color and a distinctive aroma characteristic of the Averrhoa bilimbi L. leaf extract. Furthermore, results showed that viscosity increased with the concentration of Carbopol 940, with the 0.6% formulation achieving the highest stability. However, all formulations had a pH range of 6.49 to 6.85, above the ideal skin range of 4.5–6.5. Quantitatively, significant differences in viscosity among the formulations were observed, while pH variations were not significant. The conclusion of the study confirmed that the Carbopol 940 concentration significantly affect viscosity, but further adjustments are needed to optimize the gel's pH to meet skin standards and enhance efficacy as a hygiene product.

FORMULASI PERONA PIPI DENGAN KOMBINASI PEWARNA EKSTRAK BUAH BUNI (Antidesma bunius L) DAN EKSTRAK KELOPAK ROSELLA (Hibiscus sabdariffa L) SEBAGAI PEWARNA

Elsa Marliana — 2024-03-31

The coloring agent plays important role in blush on preparation. Antidesma bunius L fruit and Hibiscus sabdariffa L flower are natural and harmless colorants. Both have anthocyanin content, which contributes to their color. In this study, the formulation of blush using a combination of Antidesma bunius fruit extract and Hibiscus sabdariffa L flower is developed. pH, temperature, and light intensity can all have an impact on anthocyanin stability. The extraction process is carried out using the maceration method, with 70% ethanol as the solvent and citric acid added to maintain the stability of the anthocyanin. Blush on is developed as a cream with a combination of both extracts in varying concentrations. The combination of both extracts not only maintains the pigment's stability at pH 3, 4, and 5, but also increases antioxidant activity, as a highly potent antioxidant with an IC₅₀ value of 40 ppm. The blush on formulation using a 2:1 ratio of Antidesma bunius L fruit extract and Hibiscus sabdariffa L flower extract, with concentration of 80 times IC50 (F3K), shows sufficient physical qualities, antioxidant activity (IC50 = 231.55 ppm), and stable pigments. Based on these findings, the combination of Antidesma bunius L fruit extract and Hibiscus sabdariffa L flower extract could be used as an alternative natural coloring in cosmetics with antioxidant activity.

PERBANDINGAN GEJALA KEJADIAN IKUTAN PASCA IMUNISASI SETELAH VAKSIN COVID-19 ASTRAZENECA PERTAMA DAN KEDUA DI CENTRAL VAKSINASI UTA 45 JAKARTA

Stefanus Lukas — 2024-03-31

Post-Immunization Adverse Events (AEFI) are common among vaccine participants. AEFI needs to be evaluated because Covid-19 vaccination is an effort to prevent Covid-19 infection which is still relatively new and people are still afraid of post-immunization adverse events occurring. In order for community participation to increase, it is deemed necessary to carry out an AEFI evaluation for both the first dose and the second dose (complete dose). This study aims to evaluate the symptoms of AEFI 1 with AEFI 2 by measuring the number of respondents who caused local and systemic reactions after COVID-19 vaccination. The retrospektive and prospective cross sectional study were used in this study with about 113 Astrazeneca vaccine participants at the UTA'45 Jakarta vaccine center and the data met the inclusion and exclusion criteria. Data was collected through questionnaires, AEFI forms and interviews based on symptoms of local and systemic reactions. Of the 113 participants, 29 were female, while 84 were male and the reactions they caused were different, such as pain, redness, swelling at the injection site, such as fever, muscle aches throughout the body, joint pain and also weakness. Comparison of symptoms of local and systemic reaction between KIPI 1and KIPI 2. In those without symptoms, there was increase number, but in those with symptoms, the number of respondens decrease, and statistically there was sig, P value <0,05.