HUBUNGAN DRUG RELATED PROBLEMS (DRPs) KATEGORI DOSIS OBAT AMLODIPIN DAN KAPTOPRIL TERHADAP KONDISI TEKANAN DARAH PADA PASIEN HIPERTENSI

Authors

  • Husnatika Jurusan Farmasi, Fakultas Kedokteran, Universitas Tanjungpura, Pontianak Indonesia
  • Nurmainah Jurusan Farmasi, Fakultas Kedokteran, Universitas Tanjungpura, Pontianak
  • Shoma Rizkifani Jurusan Farmasi, Fakultas Kedokteran, Universitas Tanjungpura, Pontianak

DOI:

https://doi.org/10.36387/jiis.v8i2.1381

Keywords:

Amlodipine, Drug Related Problems, Hypertension, Captopril

Abstract

The incidence of drug-related problems (DRPs) in the dose category on the use of antihypertensive drugs has been associated with the failure of the patient's optimal blood pressure target. The study aims to analyze the relationship between drug-related problems (DRPs) on administering amlodipine and captopril drugs to the blood pressure conditions of elderly hypertensive patients in Puskesmas. This research is observational research with a cross-sectional design of analytical nature—purposive sampling techniques. The total number of samples meeting the inclusion and exclusion criteria was 435 patients. Analysis of DRPs dose category relationship data on administration of amlodipine and captopril against blood pressure conditions using a chi-square test. The results of the study showed that the characteristics of patients visited tended to be aged 65-69 years (53.33%), female (68,51%), stage II hypertensive (62.1%), amlodipine (80.92%). The incidence of the DRP dose category in stage II hypertensive (7.6%). Statistically known DRPs of amlodipine and captopril dosing categories showed different significance in each patient's condition of prehypertension (p=0.260), hypertension stage I (p = <0,001), hypertensive stage II (p<0,001). This study concludes, there is a relationship between the incidence of DRPs in the dose category in patients with stage I and stage II hypertension.

References

Alaydrus S, Toding N, 2019, Pola Penggunaan Obat Hipertensi Pada Pasien Geriatri Berdasarkan Tepat Dosis, Tepat Pasien Dan Tepat Obat Di Rumah Sakit Anutapura Palu Tahun 2019, Jurnal Mandala Pharmacon Indonesia, 5(2), 65-73.

Azizah N, Paryono, Yuliani FC, 2015, Pengaruh Senam Lansia terhadap Penurunan Tekanan Darah pada Penderita Hipertensi di Desa Sukorejo Kecamatan Wonosari Klaten, Jurnal Ilmu Kesehatan Stikes Duta Gama Klaten, 10(2), 38.

Budiana TA, Suhat, Margaretta A, 2022,Hubungan Jenis Kelamin Dan Riwayat Keluarga Dengan Kejadian Hipertensi Pada Pra Lansia Di Wilayah Kerja Puskesmas Leuwigajah 2021. Jurnal Kesehatan Kartika, 17(1), 40-43.

Djais AI, Astuti LA, 2014, Penatalaksanaan Hiperplasia Gingiva Disebabkan oleh Penggunaan Amlodipine: Sebuah Laporan Khusus, As-Syifaa, 6(2), 125-134.

Garcao JA, Cabrita J, 2015, Evaluation of A Pharmaceutical Care Program For Hypertensive Patients In Rural Portugal. Journal Am Pharm Assoc, 42(6), 41−9.

Halim MC, Andrajati R, Supardi S, 2015, Resiko Penggunaan ACEI terhadap Kejadian Batuk Kering pada Pasien Hipertensi di RSUD Cengkareng dan RSUD Tarakan DKI Jakarta, Jurnal Kefarmasian Indonesia, 5(2), 113-122.

Handayani DS, Rusli R, Ibrahim A, 2015,Analisis Karakteristik dan Kejadian Drug Related Problems pada Pasien Hipertensi di Puskesmas Temindung Samarinda, Jurnal Sains dan Kesehatan, 1(2), 80.

Ichards TR, Tobe SW, 2015, Combining Other Antihypertensive Drugs With β-blockers in Hypertension: A Focus On Safety And Tolerability, Canadian Journal of Cardiology, 30(5), 42-46.

James A., Oparil S, Carter, L, 2016, Evidence-Based Guidelines for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eight Joint National Committe. American Medical Association, 2(1), 54-55.

Kario K, Robbins J, Jeffers BW, 2014, Titration Of Amlodipine To Higher Doses: A Comparison Of Asian And Western Experience, Vascular Health and Risk Management, 9, 695-701.

Kemenkes RI, 2018, Riset Kesehatan Dasar (RISKESDAS), Balitbang, Jakarta.

Khusna N, Murdiana HE, 2021, Identifikasi Drug Related Problems (Drps) Obat Antihipertensi Pada Pasien Hipertensi Di Puskesmas Dharma Rini Temanggung, Jurnal Farmasi Dan Kesehatan Indonesia, 1(2), 13-26.

Kotruchin P, Pachirat O, Pongchaiyakul C, 2016, Efficacy and Safety of Amlodipine versus Captopril and their Combination in Hypertensive Urgency: A Randomized Controlled Trial, Journal of General Practice, 4(5), 2-7.

Lestari U, Dewi Rasmala, Riana, 2020, Kajian Penggunaan Kaptopril terhadap Pasien Hipertensi Di RSUD Raden Mattaher Jambi, Jurnal Sains, 1(2), 24-26.

Li X, Li J, Wang L, Li H et al, 2018, Effect of Amlodipine on Cardiac Function and Inflammatory Cytokines in Patients with Hypertension, Exp Ther Med, 16(3), 2051-2054.

Lutfiyati H, Yuliastuti F, Khotimah A, 2017, Pola Pengobatan Hipertensi pada Pasien Lansia di Puskesmas Windusari, Kabupaten Magelang, Jurnal Farmasi Sains Dan Praktis, 3(2), 16-17.

Nuraeni, Eni, 2019, Hubungan Usia dan Jenis Kelamin Berisiko dengan Kejadian Hipertensi di Klinik X Kota Tangerang. Jurnal JKFT: Universitas Muhammadiyah Tangerang, 4(1), 1-6.

Pandiangan CPP, Carollia N, Suwandi JF, Tarigan A, 2017, Hubungan Drug Related Problems (DRPs) Kategori Dosis Obat Anti Hipertensi dengan Kondisi Tekanan Darah di Poliklinik Rawat Jalan Penyakit Dalam RSUD Jendral Ahmad Yani Metro 2014, Jurnal Agromed Unila, 4(2), 297-298.

Ramadhan AM, Ibrahim A, Utami AI, 2015, Evaluasi Penggunaan Obat Antihipertensi Pada Pasien Hipertensi Rawat Jalan Di Puskesmas Sempaja Samarinda, Jurnal Sains Dan Kesehatan, 1(2), 84.

Sayyidah, dkk, 2020, Pola Peresepan Obat Antihipertensi pada Pasien Rawat Inap di Rumah Sakit X Periode Januari-Maret 2020, Jurnal Prosiding Senantias, 1(1), 625-633.

Syarifah NYRS, Ulfah R, 2022, Analisa Kepatuhan Minum Obat Antihipertensi pada Pasien Peserta Posyandu Lansia Kartini Surya Khatulistiwa Pontianak, Jurnal Pharmascience, 9(1), 48-59.

Tasya AC, Isnindar, Nurmainah, 2019,Kepatuhan Penggunaan Obat Antihipertensi Pada Pasien Hipertensi Dengan Menggunakan Kuesioner Morisky Medication Adherence Scale Di Puskesmas Sukadana Kabupaten Kayong Utara. Jurnal Farmasi Kalbar, 4(1), 1-14.

Unger T, Borghi C, Charchar F, Nadia A, et al, 2020, International Society of Hypertension Global, Hypertension Practice Guidelines.

Wulandari A, Ardhianingsih V, 2021, Evaluasi Pemberian dan Penggunaan Obat Antihipertensi pada Pasien Lansia di Puskesmas Sukarami Palembang, Indonesian Pharmacy and Natural Medicine Journal, 5(2), 1-7.

Published

2023-10-31

How to Cite

Husnatika, Nurmainah, & Rizkifani, S. (2023). HUBUNGAN DRUG RELATED PROBLEMS (DRPs) KATEGORI DOSIS OBAT AMLODIPIN DAN KAPTOPRIL TERHADAP KONDISI TEKANAN DARAH PADA PASIEN HIPERTENSI. Jurnal Ilmiah Ibnu Sina, 8(2), 216–229. https://doi.org/10.36387/jiis.v8i2.1381

Issue

Section

Article

Most read articles by the same author(s)