UJI EFEK ANALGETIK EKSTRAK ETANOL 96% DAUN KELAPA SAWIT (Elaeis guineensis Jacq) TERHADAP MENCIT (Mus Musculus) YANG DI INDUKSI ASAM ASETAT
DOI:
https://doi.org/10.36387/jiis.v8i2.1485Keywords:
analgetic ,, Elaeis guineensis jacq, Writhing testAbstract
In Indonesia, especially in Kalimantan, many oil palm plants (Elaeis guineensis Jacq) are found. The potential of this plant has not been fully exploited. A number of tests have been carried out, namely as an antioxidant, burn wound, larvicide and antibacterial. This research was conducted to identify the analgesic effectiveness of oil palm leaf extract (Elaeis guineensis Jacq) on white mice (mus musculus) given acetic acid. The extraction method used is meseration. The analgesic test uses a chemical stimulation method. 25 mice were divided into 5 groups (negative group Na CMC 0.5%, positive group Paracetamol, dose I 100 mg/kgBW, dose II 300 mg/kgBW, dose III 500 mg/kgBW). Each group was treated orally, after 30 minutes they were given 1% acetic acid intraperitoneally, then the total number of wriths, percent protection and one way ANOVA test were calculated. The experimental results showed that the positive control percent protection was 57.44%, dose I was 34.78%, dose II was 52.10%, and dose III was 70.87%. The results of the one way ANOVA test analysis showed significant differences between each treatment group except for dose II 300 mg/kgBB. It can be concluded that the ethanol extract of oil palm leaves (Elaeis guineensis Jacq) has effectiveness as an analgesic and at dose II 300 mg/kgBW is the most effective dose because it is close to the percent protection of the positive control (Paracetamol).
References
Afrianti, Dewi Meustika, Revi Yenti, dan Ria. (2014). Analgesic Activity Test of Ethanol Extract of Papaya Leaves (Carica papaya L.) in Male White Mice Induced by 1% Acetic Acid.. StiFa Indonesia Yayasan Perintis Padang: Padang.
Auliah, N., Thalib, M, & Latuconsina, A. A. (2019). Test of the Analgesic Effect of Ethanol Extract of Jackfruit Leaves (Artocarpus Heterophyllus Lam.) on Mice (Mus Musculus) Induced by Acetic Acid. STIKes Mega Rezky Makassar. (Vol. 1, Issue 2).
Helmidanora, R., Sukawaty Yullia, & Chairunnisa. (2018). Effectiveness of Ethanol Extract of Serunai Leaves (Chromolaena odorata L.) as an Analgesic. In Jurnal Ilmiah Ibnu Sina (Vol. 3, Issue 2).
Kartika, A. A., Fuah1, A. M., & Siregar, H. C. H., (2013). Strategy for Rat (Rattus Norvegicus) and Mice (Mus Musculus) Farming Business Development. Fakultas Peternakan Ipb.
Novrianti, I., Heriani, H, & Wijayanti, S. (2021). Testing the Effectiveness of Knob Flower Extract Spray Gel (Gomphrena Globosa L) in Healing Burns. Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi Dan Kesehatan, 6(2), 46–55. https://doi.org/10.36387/jiis.v7i1.803
Poerwosusanta, Noor, Z., H., Ali, M., Widjajanto, E., & Mintaroem, K. (2018). Potential of Dayak Onion Extract (Eleutherine Sp) as a Standardized Herbal Medicine (Oht) in Medical Treatment.. In Jurnal Ilmiah Ibnu Sina (Vol. 3, Issue 2).
Safwan, Rizki Ananda, D., Adikusuma, W. (2016). Analgesic Activity of Ethanol Extract of Melinjo Leaves (Gnetum Gnemon L.) in White Mice (Mus musculus L.). In Jurnal Ilmiah Ibnu Sina (Vol. 1, Issue 1).
Sentat, T., Indraswari, E., & Handayani, F. (2020). Test of the Analgesic Activity of the Ethanol Extract of Herb Sembukan (Paederia Foetida L.) on Male White Mice (Mus Musculus) Induced with Acetic Acid. Jurnal Ilmiah Ibnu Sina (Jiis) Ilmu Farmasi Dan Kesehatan, 5(2), 358–363. https://doi.org/10.36387/jiis.v5i2.524
Syahfitri, R. (2016). Test the activity of ethanol extract of palm oil leaves (Elaeisguineensis Jacq.) as an anti-cholesterol agent using male mice. Medan: Fakultas Farmasi. Universitas Sumatera Utara.
Tow, W. K., Sundralingam, U., Palanisamy, U. D., Goh, A. P. T., & Sivasothy, Y. (2021). Komposisi flavonoid dan sifat farmakologi elaeis guineensis jacq. Ekstrak daun: A systematic review. In Pharmaceuticals (Vol. 14, Issue 10). MDPI. https://doi.org/10.3390/ph14100961
Turner R. (1965). Metode Skrining Dalam Farmakologi. Acad. Press. New York.
Yuniar, A. Y., & Muhtadi, A. (2013). Potential Analgesic Activity of Indonesian Medicinal Plants. Farmaka. 4(3):9
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