PROFIL DISOLUSI TABLET LEPAS LAMBAT KALIUM DIKLOFENAK MENGGUNAKAN PATI PREGELATINASI TALAS PRATAMA (Colocasia esculenta (L). Schott var. Pratama)

Authors

  • Desy Nawangsari Program Studi Sarjana Farmasi, Universitas Harapan Bangsa
  • Rani Prabandari Program Studi Sarjana Farmasi, Universitas Harapan Bangsa
  • Ammanu Kurniadi Program Studi Sarjana Farmasi, Universitas Harapan Bangsa

DOI:

https://doi.org/10.36387/jiis.v9i1.1493

Keywords:

(Colocasia esculenta (L). Schott var. Pratama), Diclofenac potassium, dissolution

Abstract

Starch is one of the commonly used excipients in tablet preparations. Natural starch has limitations in the form of poor flow rate and compressibility, so it is not suitable for use in the manufacture of tablets by direct compression. One source of plants that produce starch and has not been widely developed is (Colocasia esculenta (L). Schott var. Pratama). The purpose of this study was to modify (Colocasia esculenta (L). Schott var. Pratama) starch by gelatinization used in diclofenac potassium slow-release tablets. This research is a type of laboratory experimental research that begins with the isolation of starch from taro tubers, modification of starch by pregelatinization, manufacture of diclofenac potassium slow release tablet press mass, evaluation of physical properties and finished tablet dissolution tests. The results of the printing mass test showed that the use of (Colocasia esculenta (L). Schott var. Pratama) pregelatinated starch matrix had good flowability. The results of the tablet test showed that the average tablet weight was 209 ± 3.40 mg, the diameter and thickness were 7.69 ± 0.02 and 2.82 ± 0.01 mm respectively, the hardness was 7.00 ± 0.35 kg, the friability was 0. 73 ± 0.27 % and disintegration time 65.33 ± 2.52 minutes and the dissolution results showed that within 8 hours the potassium diclofenac sustained release tablet dissolved 60.20%. Based on the physical properties and dissolution tests performed, it can be concluded that the use of pregelatinated modified starch as a matrix in diclofenac potassium slow-release tablets fulfills the specified test parameters.

References

Abhisek, D., Prashant, G., & Abhijit, A. (2017). Sustained Release Dosage Form: a Concise Review. International Journal of Pharmaceutics & Drug Analysis, 5(5), 153–160.

Allen, L. V., & Ansel, H. C. (2015). Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems (10th ed). Lippincott Williams & Wilkins.

Anggraini, D., Lukman, A., & Mulyani, R. (2016). Formulasi Tablet Lepas Lambat Natrium Diklofenak Menggunakan Pati Pisang Kepok (Musa balbisiana L) Sebagai Matriks. Jurnal Sains Farmasi & Klinis, 3(1), 25. https://doi.org/10.29208/jsfk.2016.3.1.93

Apriyanto, B. H., Rusli, R., & Rahmadani, A. (2017). Evaluasi Pati Umbi Talas (Colocasia esculenta Schott) Sebagai Bahan Pengisi Pada Sediaan Tablet Parasetamol. Proceeding of the 5th Mulawarman Pharmaceuticals Conferences, April, 23–24. https://doi.org/10.25026/mpc.v5i1.222

Aulton, M. E., & Taylor, K. M. G. (2018a). Aulton-Pharmaceutics-The-Design-and-Manufacture-of-Medicines-5th-Edition (Vol. 5, Issue 1). Elsevier.

Aulton, M. E., & Taylor, K. M. G. (2018b). Aulton’s Pharmaceutics The Design and Manufacture of Medicines (5th ed). Elsevier.

Ayu, N. H., & Dicky, A. Y. (2013). Isolasi Amilosa Dan Amilopektin Dari Pati Kentang. Teknologi Kimia Dan Industri, 2(3), 57–62. http://ejournal-s1.undip.ac.id/index.php/jtki

Departemen Kesehatan RI. (2014). Farmakope Indonesia Edisi V. In Jakarta. Kementrian Kesehatan RI.

Departemen Kesehatan RI. (2020). Farmakope Indonesia edisi VI. In Departemen Kesehatan Republik Indonesia. Kementrian Kesehatan RI.

Hadisoewignyo, L., & Fudholi, A. (2013). Sediaan Solida. Pustaka Pelajar.

Hana, Y. K., Faudoneb, S. N., Zittob, G., Bonafedea, S. L., Rosascoa, M. A., & Segalla, A. I. (2017). Physicochemical Characterization Of Physical Mixture And Solid Dispersion Of Diclofenac Potassium With Mannitol. Journal of Applied Pharmaceutical Science, 7(1), 204–208. https://doi.org/10.7324/JAPS.2017.70130

Hartesi, B., Andriani, L., Anggresani, L., Whinata, M. B., Farmasi, P. S., Tinggi, S., Kesehatan, I., Ibu, H., Farmasi, J., & Jambi, P. K. (2020). Modifikasi Pati Kentang Secara Pregelatinasi dengan Perbandingan Pati dan Air (1: 1,25). Riset Informasi Kesehatan, 9(2), 177–187. https://doi.org/10.30644/rik.v8i2.431

Hassan, I. Z., Duncan, N., Adawaren, E. O., & Naidoo, V. (2018). ould The Environmental Toxicity Of Diclofenac In Vultures Been Predictable If Preclinical Testing Methodology Were Applied. Environmental Toxicology and Pharmacology, 64(July), 181–186. https://doi.org/10.1016/j.etap.2018.10.006

Hidayati, N., Meilany, N., & Andasari, S. D. (2020). Formulasi Tablet Kunyah Asetosal Dengan Variasi Konsentrasi PVP Sebagai Bahan Pengikat. Jurnal Ilmu Farmasi, 11(1), 7–14.

Irhami, Anwar, C., & Kemalawaty, M. (2019). Karakteristik Sifat Fisikokimia Pati Ubi Jalar Dengan Mengkaji Jenis Varietas Dan Suhu Pengeringan. Jurnal Teknologi Pertanian, 20(1), 33–44.

Ismail, I., Fitriani, L., & Leboe, D. W. I. W. (2018). Potensi Pati Umbi Tire ( Amorphophallus oncophyllus ) Taut Silang Fosfat Sebagai Matriks Tablet Lepas Lambat. Prosiding Seminar Nasional Megabiodiversitas Indonesia, April, 38–42.

Jiang, C., Cai, S., Mao, L., & Wang, Z. (2020). Effect Of Porosity On Dynamic Mechanical Properties And Impact Response Characteristics Of High Aluminum Content PTFE/Al Energetic Materials. Materials, 13(1). https://doi.org/10.3390/ma13010140

Khairunnisa, R., Nisa, M., Riski, R., & Fatmawaty, A. (2016). Evaluasi Sifat Alir Dari Pati Talas Safira (Colocasia esculenta var Antiquorum) Sebagai Eksipien Dalam Formulasi Tablet. Journal of Pharmaceutical and Medicinal Sciences, 1(1), 22–26.

Muhammad, & Barbara. (2015). Hydrophilic Matrices for Oral Control Drug Delivery. American Journal of Pharmacological Sciences, 10(5), 103–109.

Nawangsari, D. (2019). Pengaruh Bahan Pengisi Terhadap Massa Cetak Tablet Vitamin C. Viva Medika: Jurnal Kesehatan, Kebidanan Dan Keperawatan, 11(02), 37–42. https://doi.org/10.35960/vm.v11i02.464

Nawangsari, D., & Prabandari, R. (2021). Karakterisitik Massa Cetak Tablet Kunyit (Curcuma Longa. Linn) Menggunakan Avicel ® Ph 102 sebagai Bahan Pengikat. Seminar Nasional Penelitian Dan Pengabdian Kepada Masyarakat (SNPPKM), 102, 1532–1536.

Nofriyaldi, A., Suhardiana, E., & Juniarin, A. (2020). Pengaruh Penambahan Avicel PH 102 Terhadap Sifat Fisik Tablet Ekstrak Daun Pepaya (Carica papaya L.) Secara Kempa Langsung, Pengaruh Penambahan. Journal of Pharmacopolium, 3(2), 50–57.

Nurliani, L., Dwiratna, S., & Prawiranegara, B. M. P. (2019). Analisis Penjadwalan Irigasi pada Budidaya Tanaman Talas Pratama (Colocasia esculenta (L). Schott var. Pratama) Menggunakan CROPWAT 8.0. Jurnal Teknotan, 13(2), 47. https://doi.org/10.24198/jt.vol13n2.3

Octavia, M., Syukri, Y., & Firdaus, F. (2019). Pengembangan Eksipien Sediaan Tablet Dari Pati Singkong Termodifikasi Secara Fisikokimia Untuk Peningkatan Sifat Farmasetikanya. Medical Sains, 3(2), 119–130.

Peerapattana, J., Phuvarit, P., Srijesdaruk, V., Preechagoon, D., & Tattawasart, A. (2009). Pregelatinized Glutinous Rice Starch As A Sustained Release Agent For Tablet Preparations. Carbohydrate Polymers 80 (2010), 453-459.

Psimadas, D., Georgoulias, P., Valotassiou, V., & Loudos, G. (2012). Molecular Nanomedicine Towards Cancer : Journal of Pharmaceutical Sciences, 101(7), 2271–2280. https://doi.org/10.1002/jps

Rahayu, S., & Anisah, N. (2021). Pengaruh Variasi Konsentrasi Amprotab Sebagai Desintegrant Terhadap Sifat Fisik Tablet Ekstrak Buah Pare (Momordica Charantia L.). Jurnal Ilmiah Ibnu Sina, 6(1), 39-48. https://doi.org/10.36387/jiis.v6i1.572

Santosa, D., & Pertiwi, F. (2020). Formulasi Dan Uji Disolusi Terbanding Tablet Lepas Lambat Natrium Diklofenak Menggunakan Methocel K100M Sebagai Matriks. Indonesia Natural Research Pharmaceutical Journal, 5(2), 1–11. https://doi.org/10.52447/inspj.v5i2.1818

Sa’adah, H., Budianti S., Y., & Sandra, A. A. (2019). Formulasi Orally Disintegrating Tablet (Odt) Asetosal Dengan Variasi Konsentrasi Kombinasi Avice. Jurnal Ilmiah Ibnu Sina, 4(1), 31 - 39. https://doi.org/10.36387/jiis.v4i1.216

Sugiyanto, K. C., Palupi, D. A., & Adyastutik, Y. (2017). Evaluasi Hasil Keseragaman Ukuran, Keregasan dan Waktu Hancur Tablet Salut Film Neuralgad Produksi Lafi Ditkesad Bandung. Cendekia Journal of Pharmacy, 1(1), 34–40. https://doi.org/10.31596/cjp.v1i1.5

Susanti, I. (2019). Pengaruh Medium Disolusi dan Upaya Peningkatan Metformin. Farmaka, 17(1), 97–106.

United States Pharmacopeial Convention. (2018). The United States Pharmacopeia 28 th. United States Pharmacopeia Inc.

Yoedistira, C. D., & Ongkowijoyo, G. N. (2022). Validasi Metode Analisis Dan Pengujian Force Degradation Study Pada Merek Dagang Yang Mengandung ParacetamoL. Jurnal Ilmiah Ibnu Sina, 7(1), 92-101. https://doi.org/10.36387/jiis.v7i1.829

Zahoor, F. D., Mader, K. T., Timmins, P., Brown, J., & Sammon, C. (2020). Investigation of Within-Tablet Dynamics for Extended Release of a Poorly Soluble Basic Drug from Hydrophilic Matrix Tablets Using ATR-FTIR Imaging. Molecular Pharmaceutics, 17(4), 1090–1099. https://doi.org/10.1021/acs.molpharmaceut.9b01063

Published

2024-03-31

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How to Cite

PROFIL DISOLUSI TABLET LEPAS LAMBAT KALIUM DIKLOFENAK MENGGUNAKAN PATI PREGELATINASI TALAS PRATAMA (Colocasia esculenta (L). Schott var. Pratama) . (2024). Jurnal Ilmiah Ibnu Sina, 9(1), 12-23. https://doi.org/10.36387/jiis.v9i1.1493

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