@article{Hamzah_Ernanto_Afladhanti_Theodorus_2022, title={POTENSI DAUN TEH HIJAU (Camellia sinensis) SEBAGAI INHIBITOR MAIN PROTEASE (Mpro) COVID-19: SEBUAH STUDI MOLECULAR DOCKING}, volume={7}, url={https://e-jurnal.stikes-isfi.ac.id/index.php/JIIS/article/view/789}, DOI={10.36387/jiis.v7i2.789}, abstractNote={<p><em>Green tea is an herbal plant that has active compounds including anti-inflammatory, antioxidant, anti-allergic, and antiviral compounds. A previous study, flavonoid compound in tea leaves has been proven as antiviral. The development of effective antiviral drugs against COVID-19 remains a challenge for researchers across the world. A previous study investigated the role of the main protease enzyme (M<sup>pro</sup>) which is useful in the viral life cycle as a promising drug target. This study aims to know the potential compounds of green </em><em>tea</em><em> leaves</em> <em>as a COVID-19 M<sup>pro</sup> inhibitor using molecular docking. 12 compounds and lopinavir were used</em><em>. Lipinski analysis was carried out to assess potential compounds as a drug. </em><em>Docking was carried out by Autodock Tools 1.5.6 and Autodock Vina. The visualization was carried out by Discovery Studio v16. The results showed that all compounds compiled the criteria as a drug based on Lipinski</em><em> rules</em><em>. Catechin and epicatechin have the same energy bond as lopinavir with a binding energy of  -7.1 kcal/mol. Catechin gallate and epicatechin gallate have the strongest energy bond with a binding energy of -9.0 and -8.2 kcal/mol. All compounds bind in the active site of the COVID-19 M<sup>pro</sup> so they are competitive inhibitor. Catechin gallate is the strongest inhibitors. </em></p>}, number={2}, journal={Jurnal Ilmiah Ibnu Sina}, author={Hamzah, Haidar Ali and Ernanto, Junoretta Haviva and Afladhanti, Putri Mahirah and Theodorus, Theodorus}, year={2022}, month={Oct.}, pages={212–222} }