EFEK SITOTOKSISITAS SENYAWA BIOAKTIF TUMBUHAN TERHADAP SEL KANKER PAYUDARA -SKBR3 CELL LINE : A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.36387/jifi.v6i1.1367Keywords:
SKBR3, Plant compounds, Breast cancer, Cell cultureAbstract
SKBR3 cancer cells are cell cultures isolated from pleural effusion of a 43-year-old Caucasian woman with metastatic breast cancer. Many plant species are used in alternative medicine which has increased in recent decades for purposes related to breast cancer. The purpose of this systematic review is to make it easier to study the potential of bioactive compounds of medicinal plants and to analyze the effects of medicinal plants on cancer cells. This study uses a search strategy to retrieve articles, including the following items: related scientific questions, database to be used, selection of keywords, inclusion and exclusion criteria, definition of results and conclusions regarding the selected articles. Eight articles that met the inclusion criteria and had compounds derived from plants were tested in vitro on the SKBR3 cell line to see their toxicity. These plant bioactive compounds play an important role in the proliferative phase, cell cycle, fatty acid synthesis and apoptosis of cancer cells.
References
Qodria L, Nur Rachma MY. 2020. Pemilihan Sel yang Tepat Untuk Penelitian Kanker Payudara, Biotrends, Vol 11(2) : 17-28.
Rizki MI, Nurlely N, Fadlilaturrahmah F, Ma'shumah M. Skrining Fitokimia dan Penetapan Kadar Fenol Total Pada Ekstrak Daun Nangka (Artocarpus heterophyllus), Cempedak (Artocarpus integer), dan Tarap (Artocarpus odoratissimus) Asal Desa Pengaron Kabupaten Banjar. JIFI [Internet]. 2021Jun.1 [cited 2023May8];4(1):95-102. Available from: https://e-jurnal.stikes-isfi.ac.id/index.php/JIFI/article/view/667
Ilyas M, Susanty S, Jabbar A, Ermawati H. Uji Toksisitas Akut dan Gambaran Histologi Hepar Mencit (Mus musculus) Yang Diberikan Ekstrak Terpurifikasi Batang Galing (Cayratia trifolia L. Domin). JIFI [Internet]. 2018Jun.1 [cited 2023May8];1(1):145 - 11. Available from: https://e-jurnal.stikes-isfi.ac.id/index.php/JIFI/article/view/167
Yanuarto T, Novia D, Lestari SP. Formulasi Sediaan Sirup Sari Buah Senggani (Melastoma malabathricum L.). JIFI [Internet]. 2022May27 [cited 2023May8];5(1):130-9. Available from: https://e-jurnal.stikes-isfi.ac.id/index.php/JIFI/article/view/914
Puspitasari D, Pratimasari D, Andriani D. Penentuan Nilai Spf (Sun Protection Factor) Krim Ekstrak Etanol Bunga Telang (Clitoria ternatea) Secara In Vitro Menggunakan Metode Spektrofotometri. JIFI [Internet]. 2019May29 [cited 2023May8];2(1):118-25. Available from: https://e-jurnal.stikes-isfi.ac.id/index.php/JIFI/article/view/304
Kumalasari E, Nazir MA, Putra AMP. Penetapan Kadar Flavonoid Total Ekstrak Etanol 70% Daun Bawang Dayak (Eleutherine palmifolia L.) Dengan Metode Spektrofotometri UV-VIS. JIFI [Internet]. 2018Dec.27 [cited 2023May8];1(2):201-9. Available from: https://e-jurnal.stikes-isfi.ac.id/index.php/JIFI/article/view/231
Dai X, Cheng H, Bai Z, Li J. 2017. Breast cancer cell line classification and its relevance with breast tumor subtyping. J Cancer.; Vol 8(16): 3131-3141
Sampaio, R.F., Mancini, M.C., 2007. Estudos de revisão sistemática: ´ um guia para sÃntese criteriosa da evidˆencia cientÃfica. Braz. J. Phys. Ther. 11 (1), 83–89.
Jazayeri SB, Saadat S, Ramezani R, Kaviani A. 2015. Incidence of primary breast cancer in Iran: Ten-year national cancer registry data report. Cancer Epidemiol. Vol 39 (4) : 519 -27.
Hosseini A, Ghorbani A. 2015. Cancer therapy with phytochemicals: evidence from clinical studies. Avicenna J Phytomed. Vol 5 (2) : 84 -97.
Wu TS, Jiang ZS, Meng CY. Pharmacosomes of Emodin in Improving Paraplegia in Traumatic Spinal Cord Injury Rat Model. J Biomaterials Tissue Engin. 2015; 5 (12) : 991 -5.
Rezapour KM, Kazerouni F, Omrani MD, Rahimipour A, Shanaki M, et al. 2017. Cytotoxic Effect of Emodin on Growth of SKBR3 Breast Cancer Cells. Int J Cancer Manag. Vol 10(4):e8094.
Younesian O, Kazerouni F, Dehghan N, Omrani D, Rahimipour A. 2017. Effect of Curcumin on Fatty Acid Synthase Expression and Enzyme Activity in Breast Cancer Cell Line SKBR3. Int J Cancer Manag. Vol 10(3):e8173.
Yeo SK, Ali AY, Hayward OA, Turnham D, Jackson T, Bowen ID, et al. 2016. β-Bisabolene a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines. Phytother Res. Mar;30(3):418-25.
Khare, N., Chandra, S. 2018. Stevioside mediated chemosensitization studies and cytotoxicity assay on breast cancer cell lines MDA-MB-231 and SKBR3. Saudi Journal of Biological Sciences.
Zambrano, A,. Rosa, Arvelo, F,. Felipe, S. 2018. Cytotoxic and antioxidant properties in vitro of functional beverages based on blackberry (Rubus glaucus benth) and soursop (Annona muricata L) pulps, Functional Foods in Health and Disease, Vol 8(11), p. 531.
Najjari, N., Soyasai., Mostafa, S., Hamidreza, K., Ali, N. 2022 “Formulation optimization and characterization of Pistacia atlantica Desf. essential oil-loaded nanostructured lipid carriers on the proliferation of human breast cancer cell line SKBR3 (in vitro studies),†Journal of Herbal Medicine, 36, p. 100600.
Tabassam Q, Mehmood T, Ahmed S, Anwar F, Rauf RA. 2020. Characterization and anticancer potential of Withania somnifera fruit bioactives (a native species to Pakistan) using gas chromatography-mass spectrometer, nuclear magnetic resonance and liquid chromatography-mass spectrometry-electrospray ionization. J Tradit Chin Med. Vol 42(6):908-918.
Sharathna P., Alisha P, Sasikumar A, Ayisha.,Shibi, Sivan., Kaustabh, Ravi, S, Radhakrishnan. 2021. “Mirabijalones rotenoids from rhizomes of white mirabilis Jalapa Linn. and their cell proliferative studies,†Phytochemistry Letters, 44, pp. 178–184
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Jurnal Insan Farmasi Indonesia
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
