EVALUASI TEPAT PASIEN, TEPAT OBAT DAN TEPAT DOSIS ANTIPSIKOTIK PASIEN RAWAT INAP SKIZOFRENIA PARANOID DI RSJ SAMBANG LIHUM
DOI:
https://doi.org/10.36387/jifi.v7i2.2140Keywords:
Drug Use, Paranoid Schizophrenia, Antipsychotics, PANSS- ECAbstract
Schizophrenia is a severe brain disorder which is a combination of hallucinations, delusions, disordered thinking and behavioral disturbances. Paranoid schizophrenia is known to be the most common type in Sambang Lihum Hospital in 2023. The main therapy for the treatment at schizophrenia is antipsychotics with a strong effect, which treat behavioral disorders, including psychosis. Improvement of symptoms seen from the PANSS-EC which is an assessment instrument in patients with severe mental disorders/schizophrenia, so that rationality is very important to consider the principle of clinical use benefits. This study aims to determine the percentage pattern of use and rationality of antipsychotics on the successful outcomes of paranoid schizophrenia patients at Sambang Lihum Sambang Hospital, South Kalimantan in 2023.The results of the study showed that the most common drug use patterns in the typical-atypical combination category were haloperidol and clozapine, and the rationality for accuracy was 100% correct dose, 100% correct drug and 99.1% correct patient, with the outcome of successful PANSS-EC discharge of ≤ 15 was 100%.
References
Kemenkes. Survei Kesehatan Indonesia (SKI) 2023. Badan Kebijakan Pembangunan Kesehatan | BKPK Kemenkes https://www.badankebijakan.kemkes.go.id/hasil-ski-2023/ (2024).
Tandon, R. et al. Definition and description of schizophrenia in the DSM-5. Schizophr. Res. 150, 3–10 (2013).
Lähteenvuo, M. & Tiihonen, J. Antipsychotic Polypharmacy for the Management of Schizophrenia: Evidence and Recommendations. Drugs 81, 1273–1284 (2021).
Kakar, G. et al. A Phenomenal Depiction of Paranoid Schizophrenia With Auditory Hallucinations: A Case Report. Cureus 15, e46092 (2023).
Mulyani, N. S. Komunikasi Pribadi Kepala Instalasi Farmasi RSJD SambangLihum Provinsi Kalimantan. (2023).
Purwandityo, A. G. et al. The Influence of Antipsychotic to Decrease the Score of The Positive and Negative Syndrome Scale-Excited Component. Indones. J. Clin. Pharm. 7, 19–29 (2018).
Yulianty, M. D., Cahaya, N. & Srikartika, V. M. Studi Penggunaan Antipsikotik dan Efek Samping pada Pasien Skizofrenia di Rumah Sakit Jiwa Sambang Lihum Kalimantan Selatan. J. Sains Farm. Klin. 3, 153–164 (2017).
Sulampoko, P. Evaluasi Pola Pengobatan Pada Pasien Skizofrenia Rawat Inap Di Rumah Sakit Jiwa Grhasia Yogyakarta Periode Januari – Desember 2018. (2021).
Indriani, A., Ardiningrum, W. & Febrianti, Y. Studi Penggunaan Kombinasi Antipsikotik pada Pasien Skizofrenia di Rumah Sakit Yogyakarta. Maj. Farmasetika 4, 201–211 (2020).
Republik Indonesia. UU No. 20 Tahun 2003. Database Peraturan | JDIH BPK http://peraturan.bpk.go.id/Details/43920/uu-no-20-tahun-2003 (2003).
Kurniawan, Y. & Sulistyarini, I. Komunitas Sehati (Sehat Jiwa dan Hati) Sebagai Intervensi Kesehatan Mental Berbasis Masyarakat. INSAN J. Psikol. Dan Kesehat. Ment. 1, 112–124 (2016).
Fahrul, Mukaddas, A. & Faustin, I. Rasionalitas Penggunaan Antipsikotik pada Pasien Skizofrenia di Instalasi Rawat Inap Jiwa RSD Madani Provinsi Sulawesi Tengah Periode Januari-April 2014. Online J. Nat. Sci. 3, 18–29 (2014).
Zhang, J.-P. et al. Efficacy and safety of individual second-generation vs. first-generation antipsychotics in first-episode psychosis: a systematic review and meta-analysis. Int. J. Neuropsychopharmacol. 16, 1205–1218 (2013).
Maslim, R. PEDOMAN DIAGNOSTIK PPDGJ-III - PDF Free Download. adoc.pub https://adoc.pub/pedoman-diagnostik-ppdgj-iii.html (2019).
Haaker, J., Menz, M. M., Fadai, T., Eippert, F. & Büchel, C. Dopaminergic receptor blockade changes a functional connectivity network centred on the amygdala. Hum. Brain Mapp. 37, 4148–4157 (2016).
Schmitz, I. et al. The Janus face of antipsychotics in glial cells: Focus on glioprotection. Exp. Biol. Med. Maywood NJ 248, 2120–2130 (2023).
Khokhar, J. Y., Henricks, A. M., Sullivan, E. D. K. & Green, A. I. Unique Effects of Clozapine: A Pharmacological Perspective. Adv. Pharmacol. San Diego Calif 82, 137–162 (2018).
Hasni, D., Ridho, M. & Anissa, M. Gambaran Sindrom Ekstrapiramidal Pada Pasien Skizofrenia Yang Mendapat Terapi Antipsikotik. J. Kedokt. YARSI 27, 090–094 (2020).
Ikawati, Z. Farmakoterapi Penyakit Sistem Syaraf Pusat. in (2011).
Maharani, F. Kajian penggunaan obat antipsikosis pada pasien skizofrenia di unit rawat inap Rumah Sakit Grhasia Propinsi Daerah Istimewa Yogyakarta periode Januari-Desember 2003. in (2004).
Dirjen Farmalkes. Pedoman Pelayanan Kefarmasian Untuk Pasien Gangguan Jiwa | Direktorat Jenderal Kefarmasian dan Alat Kesehatan. https://farmalkes.kemkes.go.id/en/2021/09/pedoman-pelayanan-kefarmasian-untuk-pasien-gangguan-jiwa/ (2021).
Dania, H. et al. Hubungan Pemberian Terapi Antipsikotik terhadap Kejadian Efek Samping Sindrom Ekstrapiramidal pada Pasien Rawat Jalan di Salah Satu Rumah Sakit di Bantul, Yogyakarta. Indones. J. Clin. Pharm. 8, (2019).
Zimbron, J., Khandaker, G. M., Toschi, C., Jones, P. B. & Fernandez-Egea, E. A systematic review and meta-analysis of randomised controlled trials of treatments for clozapine-induced obesity and metabolic syndrome. Eur. Neuropsychopharmacol. J. Eur. Coll. Neuropsychopharmacol. 26, 1353–1365 (2016).
Hariyanto, Putri & Untari. Perbedaan Jenis Terapi Antipsikotik terhadap Lama Rawat Inap Pasien Skizofrenia Fase Akut di RSJD Sungai Bangkong Pontianak | Semantic Scholar. https://www.semanticscholar.org/paper/Perbedaan-Jenis-Terapi-Antipsikotik-terhadap-Lama-Ih-Putri/fe3d4d49ab0e4ed755d609b6f8c58293185ad5c7 (2016).
Fujimaki, K., Takahashi, T. & Morinobu, S. Association of typical versus atypical antipsychotics with symptoms and quality of life in schizophrenia. PloS One 7, e37087 (2012).
DiPiro , J., Talbert, R. & Yee, G. Farmakoterapi: Pendekatan Patofisiologis. Edisi Ke-10. vol. 1 (Jakarta : EGC, 2021; ©2018 Penerbit Buku Kedokteran EGC, 2018).
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