EFEKTIVITAS EKSTRAK ETANOL DAN EKSTRAK KLOROFORM SIPUT ONCHIDID (Onchidium thyphae) SEBAGAI PENUMBUH RAMBUT PADA TIKUS (Rattus norvegicus)
DOI:
https://doi.org/10.36387/jifi.v7i3.2217Keywords:
Onchidiid slug, In vivo, candlenut oil, hair growth, Wistar strain male rat, hair growtht, Wistar strain male ratAbstract
Hair loss is a problem that can affect appearance. A natural ingredient that can address hair loss treatment is the extract of the onchidiid snail. This study aims to test the hair growth effectiveness of ethanol and chloroform extracts of the onchidiid snail on white rats (Rattus norvegicus). The test groups of rats were divided into several groups: the Negative Group (CN), the Positive Group (CP) with candlenut oil, Treatment Group I (K1) with Chloroform Extract of the Onchidiid Snail, and Treatment Group II (K2) with Ethanol Extract of the Onchidiid Snail. Hair growth length was measured daily and processed using Image J software. The hair growth effectiveness test showed that over 14 days, the chloroform extract (K1) produced faster results compared to the other three groups, with a hair growth result of 1.61 cm on the 14th day. The findings of this study conclude that the chloroform extract of the onchidiid snail effectively promotes hair growth in male Wistar strain white rats.
References
1.Vania, I., Nofianti, T., Rahayuningsih, N. (2019). “Uji Aktivitas Ekstrak Etanol Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) sebagai Hair Tonic pada Kelinci Jantan Galur Lokal”. Pharmacoscript. 2(1): 65-76.
2.Lasisi T, Smallcombe JW, Kenney WL, Shriver MD, Zydney B, Jablonski NG, et al.(2023). Human scalp hair as a thermoregulatory adaptation. Proc Natl Acad Sci U S A. 120(24).
3. Hasanah, A., Barkah, D, C., Aisya, D., & Yuniarsih, N. (2022). Aktivitas anti alopecia sediaan hair tonic dari berbagai tanamam. Jurnal Health Sains. 3(6), 782-792.
4.Harris, B. (2021) ‘Kerontokan Dan Kebotakan Pada Rambut Hair’, Ibnu Sina: Jurnal Kedokteran dan Kesehatan, 20(2), 159–168.
5.Diana W, Wahini M, Si M.(2014) Penggunaan ekstrak buah alpukat dan madu sebagai bahan aktif hair tonic untuk rambut rontok. Journal Eletronic, 03(01):226–35
6.Tampubolon, M. I., Fadhilah, D. N., & Hutauruk, D. (2024). Formulasi Dan Evaluasi Sediaan Shampo Ekstrak Etanol Daun Cengkeh (Syzygium Aromaticum L) Sebagai Penumbuh Rambut Pada Tikus Putih Jantan. Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF), 2(3), 202-210.
7.Wall D, Meah N, Fagan N, York K, Sinclair R. (2022), Advances in hair growth. Fac Rev.;11:1.
8.Fitriani K, Slamet S, Pambudi DB, Waznah U. (2021), Aktivitas Pertumbuhan Rambut Hair Tonic Ekstrak Daun Bandotan (Ageratum conyzoides L.) Pada Kelinci Jantan (Oryctolagus Cuniculus). Prosiding Seminar Nasional Kesehatan. 8(1):1194–204.
9.Triarini, D., & Hendriani, R. (2019). Tanaman Herbal dengan Aktivitas Perangsang Pertumbuhan Rambut. Fakultas Farmasi Universitas Padjajaran, 14, 1–10.
10.Fernandes C, Medronho B, Alves L, Rasteiro MG.(2023), On Hair Care Physicochemistry: From Structure and Degradation to Novel Biobased Conditioning Agents. Polymers.;15(3):608.
11.Astuti, S. T., Hardiyati, I., & Fajar, I. R. F. (2024). Formulasi Sediaan Hair Tonic Kombinasi Fraksi Daun Binahong (Anredera cordifolia (Ten.) Steenis) dan Lendir Bekicot (Lissachatina fulica) sebagai Penumbuh Rambut. Jurnal Kesehatan Perintis, 11(1), 86-97.
12.Hidayah, R, N., Gozali, D., Hendriani, R, & Mustarichie, R. (2020). Formulasi dan evaluasi sediaan herbal hair tonic sebagai perangsang pertumbuhan rambut. Jurnal Majalah Farmasetika. 5 (5), 218-232.
13.Saputra Yasir A.(2019), Uji Aktivitas Pertumbuhan Rambut Kelinci Jantan Dari Sediaan Hair Tonic Yang Mengandung Ekstrak Etanol Daun Mangkokan. Jurnal Farmasi Malahayati. Jurnal Farmasi Malahayati.2(1):275–85
14.Zgonc Škulj A, Poljšak N, Kočevar Glavač N, Kreft S.(2020) Herbal preparations for the treatment of hair loss. Arch Dermatol Res. 3;312(6):395–406.
15.Wijianto B, Nurhidayah AL, Luliana S.(2022), Standardization of secondary metabolites and heavy metal contamination assay on onchidiid slug (onchidium typhae) west kalimantan waters. Jurnal Farmasi Sains dan Praktis. 31;8(3):199–206.
16.Wijianto B, Hamzah H, Nurhidayah AL, Kemuning GI, Dyas RAA. (2022), Characterization of Onchidiid Slug (Onchidium typhae) West Kalimantan Waters as Antibacterials and Antifungal. Borneo Journal of Pharmacy. 28;5(1):35–41
17.Rasouli, Hassan, Mohammad Hosein Farzaei, and Reza Khodarahmi. (2017) “Polyphenols and Their Benefits: A Review.” International Jour-nal of Food Properties, 20(00): 1700–1741.
18.Sari, D. Y., Widyasari, R., & Puspita, W. (2021). Formulasi Hair Tonic dari Ekstrak Etanol, Fraksi Etanol, dan Fraksi Kloroform-Metanol Kayu Secang (Caesalpinia sappan L.). Jurnal Farmasi Indonesia, 18(2), 109-120.
19.Sembiring, P. (2024). Formulasi sediaan hair tonic ekstrak etanol daun teh hijau (camellia sinensis l.) sebagai penumbuh rambut terhadap kelinci jantan (Oryctolagus cuniculus). Jurnal Penelitian Farmasi & Herbal, 6(2), 1-8.
20.Susanti, L., Mustarichie, R., Halimah, E., Kurnia, D., Setiawan, A., & Maladan, Y. (2022) Anti-alopecia activity of alkaloids group from noni fruit against dihydro testosterone -induced male rabbits and its molecular mechanism: In vivo and in silico studies. pharmaceuticals,15(12): 1557
21.Yoon, H.S.; Kang, J.I.; Kim, S.M.; Ko, A.; Koh, Y.S.; Hyun, J.W.; Yoon, S.P.; Ahn, M.J.; Kim, Y.H.; Kang, J.H.; et al.(2019), Norgalanthamine Stimulates Proliferation of Dermal Papilla Cells via Anagen-Activating Signaling Pathways. Biol. Pharm. Bull. 42, 139–143.
22.Cai, K.; Dou, R.; Lin, X.; Hu, X.; Wang, Z.; Liu, S.; Li, C.; Li, W. (2022), Changes in Phenolic Profiles and Inhibition Potential of Macrophage Foam Cell Formation during Noni (Morinda citrifolia Linn.) Fruit Juice Fermentation. Fermentation 8, 201.
23.Febriani, Amelia, Berna Elya, and Mahdi Jufri. (2016), “Uji Aktivitas Dan Keamanan Hair Tonic Ekstrak Daun Kembang Sepatu (Hibiscus Rosa-Sinensis) Pada Per-tumbuhan Rambut Kelinci.” Jurnal Farmasi Indonesia 1(1): 259–70.
24.Shoviantari, F., Liziar, M., Bahing, A. & Agustina,L,(2019) Uji aktivitas tonik rambut nanoemulsi minyak kemiri (Aleurites moluccana L). Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia 6(2):69–73.
25.Anggraini FDP, Aprianti A, Setyawati VAV, Hartanto AA.(2022), Pembelajaran Statistika Menggunakan Software SPSS untuk Uji Validitas dan Reliabilitas. Jurnal Basicedu. 6(4):6491–504.
26.Tjandra, R. F., & Datu, O. S.(2020), Analisis Senyawa Alkaloid dan Uji Daya Hambat Ekstrak Buah Sirih (Piper betle L) terhadap Bakteri Staphylococcus epidermidis. eBiomedik, 8(2).
27.Uji Aktivitas Antioksidan Fraksi N-Heksana, Kloroform Dan Etil Asetat Ekstrak Etanol Limnocharis Flava Dengan Metode DPPH” (2018) Jurnal Insan Farmasi Indonesia, 1(2), pp. 251–259.
28.Uji Aktivitas Antioksidan Fraksi Etanol Dan Kloroform Buah Senggani (Melastoma malabathricum L.) Dengan Menggunakan Metode Penangkap Radikal Bebas DPPH (2,2-Diphenyl-1-picrilhidrazil)” (2018) Jurnal Insan Farmasi Indonesia, 1(1), pp. 104–112.
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