FORMULASI DAN EVALUASI FISIK SEDIAAN TABLET NANOPARTIKEL EKSTRAK DAUN DADANGKAK (Hydrolea spinosa L.)
DOI:
https://doi.org/10.36387/jifi.v7i3.2293Keywords:
Dadangkak leaves, Nanoparticles , Tablets, AntioxidantsAbstract
The utilization of traditional medicines offers a safer alternative for treatment, particularly regarding side effects and toxicity. One herbal plant known for its antioxidant activity is dadangkak leaves (Hydrolea spinosa L.), containing flavonoids, polyphenols, and tannins. Ethanolic extracts of dadangkak leaves with antioxidant potential need development into tablet dosage forms. This study aims to determine the optimal formula for nanoparticle tablets containing dadangkak leaf extract. The extract was obtained via maceration using 96% technical ethanol, followed by evaporation to produce a thick extract. Nanoparticles were prepared by mixing the extract with 96% technical ethanol, distilled water, a chitosan solution in acetic acid, and a NaTTP solution. Particle size was analyzed using a Particle Size Analyzer (PSA). Tablet formulations involved varying concentrations of Na alginate and Avicel PH 102, using direct compression. Results showed that Na alginate and Avicel PH 102 concentrations affected tablet physical properties. Avicel PH 102 increased hardness and disintegration time, while Na alginate increased friability. Based on evaluations, formula 2 was determined to be the best.
References
1.Ermina Pakki, Sumarheni, Aisyah F, Ismail, S.S. Formulasi Nanopartikel Ekstrak Bawang Dayak (Eleutherine americana (Aubl) Merr) dengan Variasi Konsentrasi KitosanTripolifosfat. J. T rop. Pharm. Chem 2016. Vol 3, 251–263.
2.Halliwell B, Gutteridge JM. Free Radicals in Biology and Medicine. 5th ed. Oxford: Oxford University Press; 2015.
3.Lajania, H.S., Effendi, E.M., Indriani, L., Siam, S.L. Efektivitas Kombinasi Ekstrak Daun Salam (Syzygium polyanthum) Dan Sari Labu Siam (Sechium edule (Jacq.) Sw.) Sebagai Antihipertensi Pada Tikus Jantan. J. Online Mhs. Bid. Farm. 2018. Vol 1.
4.Niah R, Kumalasari E. Profil senyawa dan aktivitas antioksidan ekstrak daun sepat (Mitragyna speciosa) dan daun dadangkak (Hydrolea spinosa L.). Jurnal Ilmiah Ibnu Sina. 2020;6(1):1-10. doi:10.36387/jiis.v6i1.607.
5.Kurniasari, D., Atun, S., 2017. Pembuatan dan Karakterisasi Nanopartikel Ekstrak Etanol Temu Kunci (Boesenbergia pandurata) pada Berbagai Variasi Komposisi Kitosan. J. Sains Dasar.2017; 6, 31. https://doi.org/10.21831/jsd.v6i1.13610
6.Kurniasari D, Atun S. Teknologi nanopartikel dalam pengembangan obat. Jurnal Farmasi Indonesia. 2017;12(1):21–30.
7.Safitri, R.A. Optimasi Formula Tablet Daun Salam (Eugenia polyantha Wight.) dengan Bahan Pengikat PVP dan Bahan Penghancur Natrium Alginat Menggunakan Metode Simplex Lattice Design. Universitas Muhammadiyah Surakarta. 2017;
8.Setiawan A, Wakhidatul Kiromah NZ, Widiastuti TC. Formulasi dan Evaluasi Sediaan Tablet Nanopartikel Ekstrak Daun Salam (Syzygium Polyanthum) dengan Variasi Konsentrasi Na Alginat dan Avicel PH 102. J Pharm Sci Res. 2020;17(1):1–10.
9.Singh S, Rai S, Pandey A, et al. Synthesis and characterization of nanoparticles for drug delivery applications. J Nanobiotechnology. 2021;19(1):95. doi:10.1186/s12951-021-00892-x.
10.Rasool S, Shamsi MA, Anwar F, et al. Phytochemical screening and antimicrobial potential of medicinal plants: A review. Int J Pharm Res. 2023;15(1):115-124. doi:10.30845/ijpr.v15i1.11872.
11.Samaras V, Basiak E, Kockar M, et al. Nanoparticles for pharmaceutical drug delivery: Preparation and applications. Biotechnol Adv. 2020;38:107694. doi:10.1016/j.biotechadv.2020.107694.
12.Fry D, Allen LV. Handbook of Pharmaceutical Excipients. 9th ed. Washington, DC: Pharmaceutical Press; 2022.
13.Mansouri M, Rezaei F, Parsa M, et al. Stability and organoleptic evaluation of herbal extract-based tablets: Effect of formulation and storage. J Pharm Biomed Sci. 2020;10(6):11-16.
14.Depkes. Farmakope Indonesia V. Jakarta: Departemen Kesehatan Republik Indonesia; 2014.
15.Patel M, Thakore S, Patel K, et al. Evaluation of the mechanical properties of tablets using different excipients. J Pharm Sci Res. 2019;11(4):1226-1231.
16.Jain D, Gaurav A, Kaur S. Influence of excipient concentration on tablet hardness and disintegration time. Int J Pharm Pharm Sci. 2018;10(3):142-148.
17.Soni R, Yadav S, Kumar S, et al. Evaluation of disintegration and dissolution characteristics of herbal tablets. J Pharm Sci. 2017;106(4):1232-1239. doi:10.1016/j.jps.2017.01.023.
18.Chaudhary R, Sharma P, Bhardwaj A, et al. Evaluation of tablet friability and its impact on pharmaceutical formulations. Int J Pharm Sci. 2019;11(6):2171-2176.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Jurnal Insan Farmasi Indonesia
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
