PROFIL PENGGUNAAN CHOP DAN RCHOP PADA PASIEN LIMFOMA NON-HODGKIN DI RSUP DR. SARDJITO
DOI:
https://doi.org/10.36387/jifi.v8i1.2529Kata Kunci:
Limfoma non-Hodgkin, CHOP, R-CHOP, Karateristik pasienAbstrak
Limfoma Non-Hodgkin (LNH) merupakan keganasan heterogen sistem limfatik dengan regimen kemoterapi CHOP dan RCHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone) sebagai pilihan utama. Data lokal mengenai karakteristik pasien menjalani pengobatan ini masih terbatas, khususnya di RSUP Dr. Sardjito. Penelitian ini mengevaluasi karakteristik pasien LNH yang menjalani kedua regimen di RSUP Dr. Sardjito (2020–2023). Penelitian ini studi observasional deskriptif dengan desain potong lintang. Data diperoleh dari rekam medis pasien dianalisis secara deskriptif. Dari total 176 pasien 80 pasien menerima regimen CHOP dan 96 R-CHOP. Mayoritas berjenis kelamin laki-laki (CHOP: 70%; R-CHOP: 60,4%) dan berusia >50 tahun dengan puncak usia 51–60 tahun pada CHOP (40%) dan >60 tahun pada R-CHOP (44,8%). Komorbiditas ditemukan pada sepertiga pasien (CHOP: 33,8%; R-CHOP: 33,3%). Stadium lanjut mendominasi (CHOP: 31,3% stadium 4; R-CHOP: 38,5% stadium 2), mayoritas menyelesaikan 6 siklus kemoterapi (CHOP: 41,3%; R-CHOP: 57,3%). Rituximab ≥550 mg banyak digunakan pada R-CHOP, siklofosfamid >1100 mg, doksorubisin 70–79 mg, dan vinkristin ≥2 mg menjadi standar pada kedua regimen. Prednison 100 mg diberikan pada mayoritas kasus. Diffuse Large B-Cell Lymphoma (DLBCL) mendominasi subtipe R-CHOP (98,96%), sementara pasien CHOP meliputi DLBCL (38,75%), FL, PTCL-NOS, dan lainnya. Temuan ini menekankan pentingnya pendekatan individual berdasarkan histopatologi dan stadium penyakit.
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