STRATEGI BERBASIS MICRONEEDLE UNTUK MENINGKATKAN EFEKTIFITAS PEMBERIAN OBAT TRANSDERMAL: LITERATURE REVIEW
DOI:
https://doi.org/10.36387/34gtrt37Keywords:
Bioavailability, drug delivery system, transdermal, microneedleAbstract
Microneedle technology has emerged as a promising innovation in transdermal drug delivery, addressing limitations found in conventional methods. Microneedles enable efficient, minimally painful drug administration and enhance the bioavailability of poorly absorbed drugs. Despite their advantages, challenges in design and material selection remain barriers to broader clinical acceptance. Microneedle formulations commonly incorporate liquid and solid lipids as excipients to improve system stability and delivery flexibility. Key parameters such as particle size (PS), polydispersity index (PDI), and encapsulation efficiency (EE) are evaluated to ensure product quality. This study began with a keyword-based literature search, yielding 189 articles. After screening and elimination, 20 journals were selected for in-depth analysis. The literature review indicates that microneedle technology significantly improves drug bioavailability, immune response, and patient comfort compared to traditional injection methods. Moreover, it shows potential in minimizing side effects and enabling more controlled drug release. This research provides insight into microneedles as a new paradigm in drug and vaccine delivery, highlighting their potential for safer and more effective clinical applications.
References
1. An H, Gu Z, Huang Z, Huo T, Xu Y, Dong Y, et al. Novel microneedle platforms for the treatment of wounds by drug delivery: A review. Colloids and Surfaces B: Biointerfaces. 2024;233:113636.
2. Alkilani AZ, McCrudden MT, Donnelly RF. Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum. Pharmaceutics. 2015;7(4):438-70.
3. Cao X, He R, Xu D, Zhao Y. Interdisciplinarity traditional Chinese medicine microneedles in skin disease treatment: Recent advances and challenges. Bioactive Materials. 2026;55:568-601.
4. Cheon H, Choi H, Kim S, Kim JH, Kim B, Kim J, et al. Surface Fluidic Microneedle Patches for Lymphatic Delivery of Diagnostic and Therapeutic Agents. Advanced Functional Materials. 2025:e13324.
5. Donnelly RF, Singh TR, Garland MJ, Migalska K, Majithiya R, McCrudden CM, et al. Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery. Adv Funct Mater. 2012;22(23):4879-90.
6. Gill HS, Prausnitz MR. Coated microneedles for transdermal delivery. J Control Release. 2007;117(2):227-37.
7. Haridass IN, Wei JCJ, Mohammed YH, Crichton ML, Anderson CD, Henricson J, et al. Cellular metabolism and pore lifetime of human skin following microprojection array mediation. Journal of Controlled Release. 2019;306:59-68.
8. Hegde NR, Kaveri SV, Bayry J. Recent advances in the administration of vaccines for infectious diseases: microneedles as painless delivery devices for mass vaccination. Drug Discovery Today. 2011;16(23):1061-8.
9. Homayun B, Lin X, Choi H-J. Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals. Pharmaceutics. 2019;11(3):129.
10. Kalluri H, Banga AK. Microneedles and transdermal drug delivery. Journal of Drug Delivery Science and Technology. 2009;19(5):303-10.
11. Kulkarni D, Gadade D, Chapaitkar N, Shelke S, Pekamwar S, Aher R, et al. Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications. Scientia Pharmaceutica. 2023;91(2):27.
12. Larrañeta E, Lutton REM, Woolfson AD, Donnelly RF. Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development. Materials Science and Engineering: R: Reports. 2016;104:1-32.
13. McAlister E, Kirkby M, Donnelly RF. 6 - Microneedles for drug delivery and monitoring. In: Li X, Zhou Y, editors. Microfluidic Devices for Biomedical Applications (Second Edition): Woodhead Publishing; 2021. p. 225-60.
14. Milewski M, Brogden NK, Stinchcomb AL. Current aspects of formulation efforts and pore lifetime related to microneedle treatment of skin. Expert Opin Drug Deliv. 2010;7(5):617-29.
15. Mitchell JR, Whitney FW. The effect of injection speed on the perception of intramuscular injection pain. A clinical update. Aaohn j. 2001;49(6):286-92.
16. Nadda R, Das DB. Optimising distribution of hollow microneedle in arrays for transdermal drug delivery considering effects of tissue compression on drug permeability. International Journal of Pharmaceutics. 2025;673:125386.
17. Nguyen HX, Tran BN, Nguyen HT, Nguyen VS, Nguyen CN. Optimization of microneedle-mediated transdermal delivery for therapeutic agents of varying molecular weights. Journal of Drug Delivery Science and Technology. 2025;114:107422.
18. Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol. 2008;26(11):1261-8.
19. Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov. 2004;3(2):115-24.
20. Reinke A, Whiteside EJ, Windus L, Desai D, Stehr E, Faraji Rad Z. The advantages of microneedle patches compared to conventional needle-based drug delivery and biopsy devices in medicine. Biomedical Engineering Advances. 2024;8:100127.
21. Ren A, Hu J, Qin C, Xia N, Yu M, Xu X, et al. Oral administration microrobots for drug delivery. Bioactive Materials. 2024;39:163-90.
22. Shen M-Y, Liu T-I, Yu T-W, Kv R, Chiang W-H, Tsai Y-C, et al. Hierarchically targetable polysaccharide-coated solid lipid nanoparticles as an oral chemo/thermotherapy delivery system for local treatment of colon cancer. Biomaterials. 2019;197:86-100.
23. Thomas BJ, Finnin BC. The transdermal revolution. Drug Discov Today. 2004;9(16):697-703.
24. Tuan-Mahmood T-M, McCrudden MTC, Torrisi BM, McAlister E, Garland MJ, Singh TRR, et al. Microneedles for intradermal and transdermal drug delivery. European Journal of Pharmaceutical Sciences. 2013;50(5):623-37.
25. Waghule T, Singhvi G, Dubey SK, Pandey MM, Gupta G, Singh M, et al. Microneedles: A smart approach and increasing potential for transdermal drug delivery system. Biomedicine & Pharmacotherapy. 2019;109:1249-58.
26. Tuan-Mahmood TM, McCrudden MT, Torrisi BM, McAlister E, Garland MJ, Singh TR, et al. Microneedles for intradermal and transdermal drug delivery. Eur J Pharm Sci. 2013;50(5):623-37.
27. Yang J, Liu X, Fu Y, Song Y. Recent advances of microneedles for biomedical applications: drug delivery and beyond. Acta Pharmaceutica Sinica B. 2019;9(3):469-83.
28. Yolai N, Shu W, O’cearbhaill ED, Modchang C, Annaidh AN. Finite element analysis of polymeric microneedle insertion into skin. Materials & Design. 2025;259:114936.
29. Zaini E, Afriyani, Fitriani L, Ismed F, Horikawa A, Uekusa H. Improved Solubility and Dissolution Rates in Novel Multicomponent Crystals of Piperine with Succinic Acid. Scientia Pharmaceutica. 2020;88(2):21.
30. Zhu DD, Lim RYD, Poh YL, Li DS, Raghavan S, Chen P. Transdermal hydrogen therapy for psoriasis using cavity-embedded double-conical microneedles. Journal of Controlled Release. 2025;388:114313.
31. Yang S, Zhang W, Gao L, Zhang J, Li J, Qiu X, et al. Customizable glucose-responsive gelatin methacryloyl-based hydrogel microneedle patches for antibacterial therapy and promoted diabetic wound healing. International Journal of Biological Macromolecules. 2025;332:148610.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Jurnal Insan Farmasi Indonesia
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
