STRATEGI BERBASIS MICRONEEDLE UNTUK MENINGKATKAN EFEKTIFITAS PEMBERIAN OBAT TRANSDERMAL: LITERATURE REVIEW
DOI:
https://doi.org/10.36387/34gtrt37Kata Kunci:
Bioavailabilitas, sistem penghantaran obat, Transdermal, microneedleAbstrak
Teknologi microneedle muncul sebagai inovasi transdermal yang menjanjikan dalam mengatasi keterbatasan metode penghantaran obat konvensional. Microneedles memungkinkan pemberian obat secara efisien dan minim rasa sakit, serta meningkatkan bioavailabilitas obat yang sulit diserap. Meskipun memiliki keunggulan, tantangan terkait desain dan material masih menjadi hambatan untuk penerimaan klinis yang lebih luas. Formulasi microneedle umumnya menggunakan lipid cair dan padat sebagai eksipien guna meningkatkan stabilitas dan fleksibilitas sistem. Evaluasi terhadap parameter kritis seperti ukuran partikel (PS), indeks polidispersitas (PDI), dan efisiensi enkapsulasi (EE) diperlukan untuk menjamin kualitas produk. Studi ini diawali dengan pencarian literatur menggunakan kata kunci relevan yang menghasilkan 189 jurnal. Setelah proses penyaringan dan eliminasi, 20 jurnal dipilih untuk dianalisis lebih lanjut. Hasil tinjauan pustaka menunjukkan bahwa teknologi microneedle memberikan peningkatan signifikan dalam bioavailabilitas, respons imun, serta kenyamanan pasien dibandingkan metode injeksi tradisional. Selain itu, teknologi ini berpotensi mengurangi efek samping dan memungkinkan pengiriman obat yang lebih terkontrol. Penelitian ini memberikan gambaran potensi microneedle sebagai paradigma baru dalam sistem penghantaran obat dan vaksin yang lebih aman dan efektif.
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