OPTIMIZATION OF BUTTERFLY PEA FLOWER (Clitoria ternatea L.) LOADED ALGINATE-XANTHAN GUM BASED PEEL-OFF GEL MASK USING RESPONSE SURFACE METHODOLOGY
DOI:
https://doi.org/10.36387/jiis.v10i1.2353Keywords:
Box-behnken Design, Clitoria ternatea L., Optimization, Peel-Off Mask GelAbstract
Butterfly pea flowers are proven to contain phenolics and flavonoids, which are natural antioxidants that can be utilized in skincare such as peel-off gel masks. This study aims to obtain the optimal formula of peel-off gel mask preparation with varying concentrations of Sodium Alginate (SA) as a gelling agent, Xanthan Gum (XG) as a viscosity modifier and Propyleneglycol (PG) as a plasticizer. Optimization of the base formula was carried out with Box-behnken Design using Design Expert v.13.0 software with test responses of pH value, viscosity, spreadability, drying time and thickness. The base optimization process was carried out with 15 formulas and the optimization results showed a significant research model with the optimum formula results of 1.5% SA, 1% XG and 10% PG with a desirability value of 0.933. The optimum formula was then made and used as a base for pee-off gel mask formula of butterfly pea extract (BFE). The stability test showed significant differences (p<0.05) for the pH, viscosity, spreadability, and thickness tests. The drying time test showed no significant difference (p>0.05) in the peel-off gel mask formula of BFE against the formula base. The results of all test responses during physical stability testing still meet the gel evaluation criteria.
References
Akmal, T., Julianti, A. I., Tanjung, Y. P., Mutiara, P., & Febriyanti, S. (2024). Pharmacy Effect of Extraction Method on Total Phenolic Content and Antioxidant Activity of Terminalia catappa (L.) Leaves. PHARMASIPHA : Pharmaceutical Journal of Islamic, 8(2), 1–11. DOI: https://doi.org/10.21111/pharmasipha.v8i2.11363
Akmal, T., P. Tanjung, Y., & P. Nurlaela, S. (2022). Formulation of Peel-off Gel Face Mask from Pandanus amaryllifolius (Roxb.) Leaves Extract. Indonesian Journal of Pharmaceutical Science and Technology, 1(1), 96. DOI: https://doi.org/10.24198/ijpst.v1i1.43015
Anandha kifli, S., Dewi, C., & Pusmarani, J. (2022). Formulasi dan Uji Aktivitas Masker Gel Peel-Off Ekstrak Etanol Bunga Asoka (Ixora coccinea L.) sebagai Antioksidan. Jurnal Pharmacia Mandala Waluya, 1(5), 232–246. DOI: https://doi.org/10.54883/jpmw.v1i5.47
Ardana, M., Aeyni, V., & Ibrahim, A. (2015). Formulasi dan Optimasi Basis Gel HPMC (Hidroxy Propyl Methyl Cellulose) dengan Berbagai Variasi Konsentrasi. Journal of Tropical Pharmacy and Chemistry, 3(2), 101–108. DOI: https://doi.org/10.25026/jtpc.v3i2.95
Ariani, F., Yunita, L., Dewi, N. T., Sukanty, N. M. W., & Isasih, W. D. (2023). Ekstraksi Alginat dari Rumput Laut Coklat (Phaeophyceae) dan Pemanfaatannya Sebagai Pengemulsi (Emulsifier) pada Produk Pangan. Nutriology : Jurnal Pangan,Gizi,Kesehatan, 4(1), 12–18. DOI: https://doi.org/10.30812/nutriology.v4i1.2859
Azizah, A. R., Rasidah, A. I., Wilujeng, F. L., Piya, N., Yuliani, S. D., Adhila, G., & Sundu, R. (2024). Formulasi Masker Gel Peel Off Ekstrak Bunga Telang (Clitoria ternatea L.) Sebagai Antioksidan Alami. Jurnal Riset Kefarmasian Indonesia, 6(1), 122–141. DOI: https://doi.org/10.33759/jrki.v6i1.477
Bushair P, Shahna, K. ., Sufair., M., Nishad, Baboo, C., & Sirajudheen. (2023). Formulation and Evaluation of Charcoal Based Herbal Peel Off Mask. International Journal of Pharmaceutical Sciences Review and Research, 81(2), 76–80. DOI: https://doi.org/10.47583/ijpsrr.2023.v81i02.014
Ermawati, D. E., Surya, A. P., Setyawati, R., & Niswah, S. U. (2022). The Effect of Glycerin and Polyethylene Glycol 400 as Humectant on Stability and Antibacterial Activity of Nanosilver Biosynthetic Peel-Off Mask. Journal of Applied Pharmaceutical Science, 12(4), 80–89. DOI: https://doi.org/10.7324/JAPS.2022.120409
Hariyadi, D. M., Isnaeni, I., Sudarma, S., Shandra, N. M. K., & Rosita, N. (2021). Formulation of Peel-Off Mask Containing Natural Antibacterial: Study on Poly Vinyl Alcohol (PVA) and Virgin Coconut Oil (VCO) Contents. Tropical Journal of Natural Product Research, 5(3), 514–518. DOI: https://doi.org/10.26538/tjnpr/v5i3.16
Indriaty, S., Nina Karlina, Nur Rahmi Hidayati, Deni Firmansyah, Rima Yulia Senja, & Yasmin Zahiyah. (2022). Formulasi dan Uji Aktivitas Deodoran Spray Ekstrak Etanol Herba Kemangi Terhadap Bakteri Staphylococcus aureus. Medical Sains : Jurnal Ilmiah Kefarmasian, 7(4), 973–982. DOI: https://doi.org/10.37874/ms.v7i4.566
Jelantik, N. P. A. C. R., & Cahyaningsih, E. (2022). Antioxidant Potential of Telang Flowers (Clitoria ternatea L.) as an Inhibitor of Hyperpigmentation due to Ultraviolet Exposure. Jurnal Ilmiah Farmasi, 18(1), 45–54. DOI: https://doi.org/10.20885/jif.vol18.iss1.art5
Krisnadi, R., Handarni, Y., & Udyani, K. (2019). Pengaruh Jenis Plasticizer Terhadap Karakteristik Plastik Biodegradable dari Bekatul Padi. Seminar Nasional Sains Dan Teknologi Terapan VII, 100, 125–130.
Lestari, U., Farid, F., & Yuliawati. (2022). Physical Properties Test Peel Off Gel Mask Based of Date Palm Seeds Powder (Phoenix dactylifera) and Olive Oil. AIP Conference Proceedings, 2453(July). DOI: https://doi.org/10.1063/5.0095458
Madu, W., Wahyuni, S., & Susilowati, P. (2022). Karakteristik Edible Film Dari Berbagai Jenis Umbi-Umbian Dengan Penambahan Gliserol: Studi Kepustakaan. Jurnal Sains Dan Teknologi Pangan, 7(1), 4824–4829.
Maharani, A. A., Husni, A., & Ekantari, N. (2017). Karakteristik Natrium Alginat Rumput Laut Cokelat (Sargassum fluitans) dengan Metode Ekstraksi yang Berbeda. Jurnal Pengolahan Hasil Perikanan Indonesia, 20(3), 478–487. DOI: https://doi.org/10.17844/jphpi.v20i3.19768
Narayanan, A., K. S, F., Babu, G., V, N., M K, R., Abraham, A., & Babu, N. (2022). Formulation and Evaluation of Skin Invigorating Caffeine Face Mask. International Journal of Pharmaceutical Sciences Review and Research, 75(14), 86–89. DOI: https://doi.org/10.47583/ijpsrr.2022.v75i02.014
Nugrahaeni, F., Srifiana, Y., & Rokhman, A. N. (2021). Pengaruh Peningkatan Konsentrasi Xanthan Gum Sebagai Basis Gel Terhadap Sifat Fisik Gel Pewarna Rambut Ekstrak Kayu Secang (Caesalpinia sappan L.) Indonesia Natural Research Pharmaceutical Journal, 6(2), 29–42.
Samsul, E., Jumain, J., & Sinala, S. (2022). Formulasi Masker Gel Peel Off Ekstrak Kulit Buah Langsat (Lansium domesticum L) dengan Variasi PVA (Polivinil Alkohol). Jurnal Mandala Pharmacon Indonesia, 8(2), 151–164. DOI: https://doi.org/10.35311/jmpi.v8i2.203
Sopyan, I., Gozali, D., Sriwidodo, & Guntina, R. K. (2022). Design-Expert Software (Doe): an Application Tool for Optimization in Pharmaceutical Preparations Formulation. International Journal of Applied Pharmaceutics, 14(4), 55–63. DOI: https://doi.org/10.22159/ijap.2022v14i4.45144
Sunarharum, W. B., Kambodji, A. D., & Nur, M. (2020). The Physical Properties of Coffee Caviar as Influenced by Sodium Alginate Concentration and Calcium Sources. IOP Conference Series: Earth and Environmental Science, 475(1). DOI: https://doi.org/10.1088/1755-1315/475/1/012021
Tonthawi, M., & Musfiroh, I. (2023). Review: Peningkatan Stabilitas Vitamin C dalam Sediaan Kosmetika. Majalah Farmasetika, 8(3), 194. https://doi.org/10.24198/mfarmasetika.v8i3.44462 DOI: https://doi.org/10.24198/mfarmasetika.v8i3.44462
Wati, G. A. S. W. T., Suriati, L., & Semariyani, A. A. M. (2023). Karakteristik Fisiko Kimia Edible Film Pulp Kopi Dengan Penambahan Kitosan. Cannarium, 21(2), 2–11. DOI: https://doi.org/10.33387/cannarium.v21i2.6974
Wijayanti, Astuti, Prasetia, Darayanthi, Nesa, Wedarini, & Adhiningrat. (2015). Profil Stabilitas Fisika Kimia Masker Gel Peel-Off Ekstrak Kulit Buah Manggis (Garcinia mangostana L.). Jurnal Farmasi Udayana, 4(1), 99–103.
Zahara, F., Yuniharni, D., & Arziqni, I. (2023). Optimasi Ekstraksi Flavonoid Dari Daun Pisang Kepok (Musa paradisiaca L) Menggunakan Microwave-Assisted Extraction (MAE). 2(November), 190–202. DOI: https://doi.org/10.29103/jtku.v12i2.13010
Downloads
Published
Issue
Section
License
Copyright (c) 2025 JIIS (Jurnal Ilmiah Ibnu Sina): Ilmu Farmasi dan Kesehatan
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
