FORMULASI KRIM EKSTRAK BIJI KUPA (Syzygium polycephalum) DAN PENENTUAN NILAI SPF (Sun Protection Factor) SECARA IN VITRO

  • Wulan Novian Dewi Universitas Bakti Tunas Husada
  • Ira Rahmiyani Universitas Bakti Tunas Husada
  • Anindita Tri Kusuma Pratita Universitas Bakti Tunas Husada
  • Resha Resmawati Shaleha Universitas Bakti Tunas Husada
Keywords: Kupa seeds, Cream, SPF, Syzygium polycephalum, Sunscreen

Abstract

The high intensity of ultraviolet rays and exposure to the sun too often can have harmful effects on the skin, so sunscreen can be used to prevent interference from UV rays. The purpose of this study was to determine the activity of sunscreen and determine the SPF value of the extract and cream preparation of Kupa (Syzygium polycephalum) seeds. In this study, the seeds of Kupa fruit were extracted by the graded maceration method using 96% ethanol, ethyl acetate, and n-hexane as solvents. The ethyl acetate extract was formulated in the form of a cream dosage form with the added concentration of Kupa seed extract, namely 0.1% (F1), 0.2% (F2), and 0.5% (F3). Furthermore, the determination of the value of sunscreen on the extract and cream preparation using UV-Vis spectrophotometry and evaluation of the physical properties of the cream preparation include organoleptic tests, homogeneity, pH tests, spreadability, adhesion, and viscosity. The results showed that the SPF values ??of ethanol, ethyl acetate, and n-hexane extracts at a concentration of 200 ppm were 14.29; 19.32, and 14.02. While the SPF value of ethyl acetate extract cream preparations of Kupa fruit seeds F1, F2, and F3 respectively was 1.97; 2.96, and 4.96. Kupa seed extract has activity as a sunscreen with maximum and ultra protection levels. While the preparation of 0.5% ethyl acetate extract of Kupa seed had sunscreen activity with moderate protection. The physical properties of the cream preparations gave good results during the test.

References

Alrosyidi, Ahmad Faruk, and H Syaifiyatul. 2021. “Formulasi , Evaluasi Mutu Fisik , Dan Uji Spf Krim Tabir Surya Berbahan Dasar Rumput Laut E. Cottonii.†Majalah Farmasi dan Farmakologi 25(April): 15–19.

Amini, A., C. D. Hamdin, W. A. Subaidah, and H Muliasari. 2020. “Efektivitas Formula Krim Tabir Surya Berbahan Aktif Ekstrak Etanol Biji Wali ( Brucea Javanica L . Merr ).†Jurnal Kefarmasian Indonesia 10(1): 50–58.

Athiyah, Meilisa, Islamudin Ahmad, and Laode Rijai. 2015. “Aktivitas Tabir Surya Ekstrak Akar Bandotan (Ageratum Conyzoides L.).†Jurnal Sains dan Kesehatan 1(4): 181–87.

Balsam, M. S, and E Sagarin, eds. 1972. Cosmetics: Science and Technology 2nd Ed., Vols. 1-3. Interscience Publishers, Inc: New York.

Geraldine, Elsa Tamara, and Ema Dwi Hastuti. 2018. “Formulation Of Sunscreen Cream Of Parijoto Fruit Extract (Medinilla Speciosa Blume) And In Vitro Spf Value Test.†Journal of Pharmaceutical Sciences and Community 15(2): 92–98.

Hasanah, Siti, Islamudin Ahmad, and Laode Rijai. 2015. “Profil Tabir Surya Ekstrak Daun Dan Fraksi Daun Pidada Merah.†Jurnal Sains dan Kesehatan 1(4): 175–80.

Isfardiyana, Siti Hapsah, and Sita Ririn Safitri. 2014. “Pentingnya Melindungi Kulit Dari Sinar Ultraviolet Dan Cara Melindungi Kulit Dengan Sunblock Buatan Sendiri.†Jurnal Inovasi dan Kewirausahaan 3(2): 126–33.

Lisnawati, Nia, M N U Fathan, and Dwi Nurlitasari. 2019. “Penentuan Nilai SPF Ekstrak Etil Asetat Daun Mangga Gedong Menggunakan Spektrofotometri Uv – Vis.†Jurnal Riset Kefarmasian Indonesia 1(2): 157–66.

Lumentut, Natalia, Hosea Jaya Edi, and Erladys Melindah Rumondor. 2020. “Formulasi Dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Kulit Buah Pisang Goroho (Musa Acuminafe L.) Konsentrasi 12.5% Sebagai Tabir Surya.†Jurnal MIPA 9(2): 42–46.

Mansur, J. S, M. N. R Breder, M. C. A Mansur, and R. D. Azulay. 1986. “Determinação Do Fator de Proteção Solar Por Espectrofotometria.†An. Bras. Dermatol., Rio de Janeiro 61: 121–24.

Nurmalasari, Trisna et al. 2016. “Uji Aktivitas Antioksidan Ekstrak Buah Kupa (Syzygium Polycephalum) Terhadap Radikal Bebas Dengan Metode DPPH.†Jurnal Kesehatan Bakti Tunas Husada 16(1): 61.

Pratiwi, Risna Rachma, Senadi Budiman, and Ginayanti Hadisoebroto. 2016. “Penetapan Kadar Nilai SPF ( Sun Protection Factor ) Dengan Menggunakan Spektrofotometri Uv-Vis Pada Krim Pencerah Wajah yang Mengandung Tabir Surya yang Beredar di Kota Bandung.†Prosiding Seminar Nasional Kimia UNJANI-HKI 2016 (December): 15–23.

Rahmiyani, Ira. 2017. “Penetapan Kadar Flavonoid Total Ekstrak Buah Kupa (Shyzigium Polycepalum Miq.) Menggunakan Spektrofotometri UV-VIS.†Jurnal Kesehatan Bakti Tunas Husada 17: 487–91.

Rohmah, Jamilatur, Chylen Setiyo Rini, and Fitria Eka Wulandari. 2019. “Aktivitas Sitotoksik Ekstrak Selada Merah (Lactuca Sativa Var. Crispa) Pada Berbagai Pelarut Ekstraksi.†Jurnal Kimia Riset 4(1): 18–32.

SNI. 1996. Sediaan Tabir Surya. Jakarta: Dewan Standardisasi Nasional.

Ulandari, Atri Sri, and N Sugihartini. 2020. “Evaluasi Sifat Fisik Sediaan Lotion Dengan Variaso Konsentrasi Ekstrak Daun Kelor (Moringa Oleifera L.) Sebagai Tabir Surya.†Jurnal Farmasi Udayana 9(1): 45–51.

Utami, Angling Nurisna, Wahida Hajrin, and Handa Muliasari. 2021. “Formulasi Sediaan Lotion Ekstrak Etanol Daun Salam (Syzygium Polyanthum (Wight) Walp.) Dan Penentuan Nilai SPF Secara in Vitro.†Pharmaceutical Journal of Indonesia 6(2): 77–83.

Wasitaatmadja. 1997. Penuntun Kosmetik Medik. Jakarta: UI-Press.

Whenny, Rolan Rusli, and Laode Rijai. 2015. “Aktivitas Tabir Surya Ekstrak Daun Cempedak (Artocarpus Champeden Spreng).†1(4): 4–8.

Wulandari, Widi, Hendri Wasito, and Sri Sutji Susilowati. 2018. “Stabilitas Fisik Dan Pengukuran Nilai Sun Protection Factor Sediaan Tabir Surya Pada Kondisi Stress Penyimpanan Dengan Spektrofotometri Physical Stability and Sun Protection Factors Measurement of Sunscreen Preparations in Stress Storage Conditions Using.†Api 6(1): 1–11.

Yanuarti, Rini, N. Nurjanah, Effionora Anwar, and Taufik Hidayat. 2017. “Profile of Phenolic and Antioxidants Activity from Seaweed Extract Turbinaria Conoides and Eucheuma Cottonii.†Jurnal Pengolahan Hasil Perikanan Indonesia 20(2): 230.

Published
2022-10-31
How to Cite
Dewi, W., Rahmiyani, I., Kusuma Pratita, A., & Shaleha, R. (2022). FORMULASI KRIM EKSTRAK BIJI KUPA (Syzygium polycephalum) DAN PENENTUAN NILAI SPF (Sun Protection Factor) SECARA IN VITRO. Jurnal Ilmiah Ibnu Sina, 7(2), 328-339. https://doi.org/10.36387/jiis.v7i2.984
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