FORMULASI DAN UJI MUTU FISIK KRIM MASKER WAJAH Anti-Aging BERBASIS FRAKSI ETIL ASETAT DAUN MIANA (Coleus scutellarioides (L) Benth)

Authors

  • Silaban Erllin Tirza Stevany stikes dirgahayu samarinda
  • Muh. Taufiqurrahman Pharmacy Study Program, STIKES Dirgahayu Samarinda
  • Nurillahi Febria Leswana Pharmacy Study Program, STIKES Dirgahayu Samarinda

DOI:

https://doi.org/10.36387/jiis.v10i1.2204

Keywords:

antianging, Cycling test, Cream, fraksi etil asetat

Abstract

One of the natural ingredients that can be used as a cosmetic ingredient is miana leaf (Coleus scutelleroides (L) Benth) which contains flavonoid compounds with antioxidant activity that can be used for skin care. These compounds can prevent free radicals that can cause premature aging. The extraction method was used in this study with 96% ethanol solvent and continued with the fractionation process. The determination of antioxidant activity was determined by calculating the IC50 value where the IC50 value of the ethyl acetate fraction of miana leaves obtained was 27.90 ppm. In the study, a formulation of face mask cream preparations with a variety of active ingredients (0,6; 1,2; 2,4). Evaluation of the preparation was carried out on the physical quality of face mask cream using the cycling test method. Based on the results of stability tests on the four preparations, formula 2 with 1.2 g of active ingredients shows the best formula. Antioxidant testing from F1, F2 and F3 obtained IC50 values of 96.33 ppm, 82.73 ppm, 72.71 ppm. The statistical test of antioxidant activity showed a p<0.05 result which indicates that there is a significant difference between the three formulas. Cycling test showed that the facial mask cream preparation was physically and chemically stable. There was no significant change in color, odor, texture, phase separation, or pH change. Viscosity also remained stable, indicating good shelf life during normal storage.

Author Biographies

  • Silaban Erllin Tirza Stevany, stikes dirgahayu samarinda

    Bachelor of Pharmacy, STIKES Dirgahayu Samarinda

  • Muh. Taufiqurrahman, Pharmacy Study Program, STIKES Dirgahayu Samarinda

    Homebase: Pharmacy Study Program, STIKES Dirgahayu Samarinda

    Position: Secretary of the Undergraduate Pharmacy Study Program

  • Nurillahi Febria Leswana, Pharmacy Study Program, STIKES Dirgahayu Samarinda
    Pharmacy Study Program, STIKES Dirgahayu Samarinda Position: Lecturer in harmacy Study Program

References

Anggowarsito, J. L., 2014. Aspek Fisiologi Penuaan Kulit, Jurnal Widya Medika, 2(1): 56-61.

Arman, I., Edy, H. J., Mansauda, K. L. R., 2021. Formulasi dan Uji Stabilitas Fisik Sediaan Masker Gel Peel-Off Ekstrak Etanol Daun Miana (Coleus scutellerioides (L.) Benth) Dengan Berbagai Basis, Jurnal Farmasi Medica, 4(1): 36-43. DOI: https://doi.org/10.35799/pmj.4.1.2021.34523

Azhar, F. S. S., Hasanah, S. N., Marthasedana, R. A., Dewilestari, M. P., Adriyani, S. R., Anggraeni, W., Suryasaputra, D., Syam, A. K., 2023. Potensi Krim Antioksidan Getah Jarak Tintir (Jatropha mulfida L.) Dalam Menghambat Enzim Tirosinase Secara In Silico Sebagai Alternatif Agen Pemutih, Jurnal Ilmiah Farmasi Farmasyifa, 6(1): 17-28. DOI: https://doi.org/10.29313/jiff.v6i1.10700

Badarinath, A., Rao, K., Chetty, C. S., Ramkanth, S., Rajan, T., Gnanaprakash K., 2010. A Review on In-vitro Antioxidant Methods: Comparisons, Correlations, and Considerations, International Journal of PharmTech Research, 1276-1285.

Barkat, A. K., Naveed A., Khan, H. M. S., Waseem, K., Tariq, M., Rasul, A., Iqbal, M., & Haroon, K., 2013. Development, characterization an antioxidant activity of polysorbate based o/w emulsion containing polyphenols derived from hippophae rhamnoides and cassia fistula, Brazilian Journal of Pharmaceutical Sciences, 49(4): 50. DOI: https://doi.org/10.1590/S1984-82502013000400016

Buang, A., 2013. Formulasi Krim Masker Wajah Menggunakan Lapisan Putih Kulit Buah Semangka (Citrullus Vulgaris Schard) Sebagai Pelembab, Skripsi, Universitas Pancasakti, Makassar.

Dhiasmi, A., Komala O., Noorlaela, E., 2017. Formulasi dan Uji Sediaan Masker Anti Jerawat Kayu Manis (Cinnamomum burmanni (Nees & T. Nees), Jurnal Program Studi Farmasi.

Dominica, D., Handayani, D., 2019. Formulasi dan Evaluasi Sediaan Lotion dari Ekstrak Daun Lengkeng (Dimocarpus Longan) sebagai Antioksidan, Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 6(1). DOI: https://doi.org/10.20473/jfiki.v6i12019.1-7

Do, Q.D., Angkawijaya, A.E., Tran-Nguyen, P.L., Huynh, L.H., Soetaredjo, F.E., Ismadji, S. & Ju, Y.H., 2014. Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica. Journal of Food and Drug Analysis, 22(3), pp.296-302. DOI: https://doi.org/10.1016/j.jfda.2013.11.001

Doan, T.L. & Nguyen, P.M., 2021. Effect of emulsifier type and concentration on the stability of oil-in-water emulsions. Journal of Emulsion Technology, 15(2), pp.45-60.

El-Sayed, W., Mohammad, T.G.M., 2014. Preparation and Characterization of Alternative Oil-in-Water Emulsion Formulation of Deltamethrin, American Journal of Experimental Agriculture, 4(4): 405-414. DOI: https://doi.org/10.9734/AJEA/2014/6372

Fauziah, Y., Nurhikma, E., Badia, E., Rusli, N., Wihaetin, W., 2023. Formulasi Masker Krim Wajah Antiaging Kombinasi Sari Wortel (Daucus carota L.) dan Madu, Warta Farmasi, 12(1): 35-45. DOI: https://doi.org/10.46356/wfarmasi.v12i1.239

Halliwell, B. & Gutteridge, J.M.C., 2015. Free radicals in biology and medicine. 5th ed. Oxford: Oxford University Press. DOI: https://doi.org/10.1093/acprof:oso/9780198717478.001.0001

Hasniar, H., Yusriadi, Y., Khumaidi, A., 2015. Formulasi Krim Antioksidan Ekstrak Daun Kapas (Gossypium sp.), Jurnal Farmasi Galenika, 1(1): 9–15. DOI: https://doi.org/10.22487/j24428744.2015.v1.i1.4830

Herdiana, I., Aji, N., 2020. Fraksinasi Ekstrak Daun Sirih dan Ekstrak Gambir serta Uji Antibakteri Streptococcus mutans, Jurnal Ilmiah Kesehatan, 19(03): 100–106. DOI: https://doi.org/10.33221/jikes.v19i03.580

Hikma, N., Rachmawati, D., Ratnah, St., 2022. Formulasi dan Uji Mutu Fisik Sediaan Body Scrub Ekstrak Kulit Buah Pepaya (Carica papaya L) dengan Variasi Konsentrasi Trietanolamin, Jurnal Mandala Pharmacon Indonesia, 8(2): 185-195. DOI: https://doi.org/10.35311/jmpi.v8i2.218

Holick, M. F., 2016. Biological effects of sunlight, ultraviolet radiation, visible light, infrared radiation and Vitamin D for health, Anticancer Research, 36(3): 1345–1356.

Ida, N., Noer, S. F., 2012. Uji Stabilitas Fisik Gel Ekstrak Lidah Buaya (Aloe vera L.), Majalah Farmasi dan Farmakologi, 16(2): 79-84.

Iordanis, P., 2020. Comparative study on the effect of solar radiation on workers’ skin at different altitudes, Journal of Dermatology & Cosmetology, 4(1): 14–18. DOI: https://doi.org/10.15406/jdc.2020.04.00142

Iskandar, B., Lukman, A., Tartilla, R., Suroboyo, M.D.C., Leny. 2021. Formulasi, Karakterisasi Dan Uji Stabilitas Mikroemulsi Minyak Nilam (Pogostemon cablin Benth.), Jurnal Ilmiah Ibnu Sina, 6(2): 282-291. DOI: https://doi.org/10.36387/jiis.v6i2.724

Kartikasari, D., Rahman, I. R., & Ridha, A., 2022. Uji fitokimia pada daun kesum (Polygonum minus Huds.) dari Kalimantan Barat, Jurnal Insan Farmasi Indonesia, 5(1), 35-42. DOI: https://doi.org/10.36387/jifi.v5i1.912

Khasanah, N. W., Karyadi, B., Sundaryono, A., 2020. Uji Fitokimia dan Toksisitas Ekstrak Umbi Hydnophytum sp. terhadap Artemia salina Leach, PENDIPA Journal of Science Education, 4(1): 47–53. DOI: https://doi.org/10.33369/pendipa.4.1.47-53

Kumalasari, M. L. F., Andiarna, F., 2020. Uji fitokimia ekstrak etanol daun kemangi (Ocimum basilicum L), Indonesian Journal for Health Sciences 4(1): 39-44. DOI: https://doi.org/10.24269/ijhs.v4i1.2279

Maitulung, I., Maarisit, W., Pareta, D. N., Lengkey, Y. K., 2022. Uji Aktivitas Antioksidan Ekstrak Etanol Akar Manukan (Rhinacanthus nasutus (L) Kurz), The Tropical Journal of Biopharmaceutical 5(2): 127–134.

Mansauda, K.L.R., Abdullah, S.S., Tunggal, R.I., 2023. Stabilitas Fisik Krim Ekstrak Kulit Buah Alpukat Dengan Variasi Perbandingan Asam Stearat dan Trietanolamin, JURNAL MIPA, 12(1): 16-21. DOI: https://doi.org/10.35799/jm.v12i1.44221

Megantara, I. N. A. P., Megayanti, K., Wirayanti,R., Esa, I. B. D., Wijayanti, N. P. A. D., Yustiantara, P.S., 2017. Formulasi Lotion Ekstrak Buah Raspberry (Rubus rosifolius) Dengan Variasi Konsentrasi Trietanolamin Sebagai Emulgator Serta Uji Hedonik Terhadap Lotion, Jurnal Farmasi Udayana, 6(1): 1-66. DOI: https://doi.org/10.24843/JFU.2017.v06.i01.p01

Nabila, Z.H., 2019. Pengaruh Konsentrasi PVA Terhadap Stabilitas dan Aktivitas Antioksidan Masker Peel Off Ekstrak Kulit Jengkol (Archidendron Pauciflorum (Benth.) Nielsen), Stikes Karya Putra Bangsa Tulungagung. DOI: https://doi.org/10.25026/jsk.v2i4.256

Podungge, M. R., Salimi, K. Y., Duengo, S., 2017. Isolasi dan Uji Aktivitas Antioksidan Senyawa Flavonoid dari Daun Miana, Jurnal Entropi, 1(1): 67–74.

Pohan, E., 2019. Formulasi Dan Uji Stabilitas Krim Ekstrak Methanol Daun Beluntas (Pluchea indica L.) Dari Kota Benteng Kabupaten Kepulauan Selayar Provinsi Sulawesi Selatan, Jurnal Farmasi Sandi Karsa, 5(1): 57–64. DOI: https://doi.org/10.36060/jfs.v5i1.36

Rabima, Marshall, 2017. Uji Stabilitas Formulasi Sediaan Krim Antioksidan Ekstrak Etanol 70% Dari Biji Melinjo (Gnetum gnemon L.), Indonesian Natural Research Pharmaceutical Journal, 2(1): 107-121.

Rahma, A. N. A., Wahini, M., 2017. Pengaruh Proporsi Daging Kurma Dan Madu Pada Sifat Organoleptik Masker Wajah Tradisional, Jurnal Mahasiswa, 06(1): 162–169.

Rahmawatti, D., Sukmawati, A., Indrayudha P., 2010. Formulasi Krim Minyak Atsiri Rimpang Temu Giring (Curcuma heyneana Val & Zijp), Majalah Obat Tradisional 15:56-63.

Rahmawaty, D., Sari, D. I., 2019. Buku Ajar Teknologi Kosmetik, CV IRDH, Purwokerto, 3; 8-11.

Segara, Y., Kurniawan, A., 2021. Uji Aktivitas Antioksidan dan Penetapan Kadar Flavonoid Total pada Ekstrak Etanol Daun Iler (Coleus scutellarioides (L.) Benth.), Jurnal Farmasi dan Farmakoinformatika, 10(10), 60–75.

Suryani, N.L.P. & Putri, I.G.A.A.I., 2021. Anti-aging potential of miana leaf extract through antioxidant mechanism. Indonesian Journal of Pharmaceutical Research, 7(1), pp.45-50.

Sulistyoningdyah, F., Ramayani, L.S., 2017. Skrining Fitokimia Ekstrak Infusa Kulit Petai (Parkia speciosa Hassk), Jurnal Jawara, 4(1).

Suryani, Putri, A. E. P., Agustyiani, P., 2017. Formulasi dan uji stabilitas sediaan gel ekstrak terpurifikasi daun paliasa (Kleinhovia Hospita L.) yang berefek antioksidan, Pharmacon, 6(3).

Thomas, N. A,. Suryadi, A.M.A., Latif, M. S., Hutuba, A.H., Susanti, S., 2024. Formulasi dan Uji Stabilitas Fisik Krim Pelembab Ekstrak Rumput Laut (Eucheuma cottonii), Indonesian Journal of Pharmaceutical, 4(1): 1-9. DOI: https://doi.org/10.37311/ijpe.v4i1.20522

Virgita, V. M., Krisnawati, M., 2014. Journal of Beauty and Beauty Health Education, Journal of Beauty, 3(1), 1–7.

Wilda, N. P., 2011. Pengaruh Agitasi Mekanik Terhadap Presipitasi CaCo3 pada Air Sadah, Skripsi, Universitas Indonesia, Depok.

Wintariani, N. P., Mahartha, I. K. P., Suwantara, I. P. T., 2021. Sifat Fisika Kimia Sediaan Vanishing Krim Anti Jerawat Ekstrak Etanol 96% Daun Belimbing Wuluh (Averrhoa bilimbi L.), Widya Kesehatan, 3(1): 26–34. DOI: https://doi.org/10.32795/widyakesehatan.v3i1.1655

Published

2025-03-31

How to Cite

FORMULASI DAN UJI MUTU FISIK KRIM MASKER WAJAH Anti-Aging BERBASIS FRAKSI ETIL ASETAT DAUN MIANA (Coleus scutellarioides (L) Benth). (2025). JIIS (Jurnal Ilmiah Ibnu Sina): Ilmu Farmasi Dan Kesehatan, 10(1), 41-55. https://doi.org/10.36387/jiis.v10i1.2204

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