EFEKTIVITAS GEL EKSTRAK DAUN BELIMBING WULUH (Averrhoa bilimbi L.) TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS PUTIH YANG DIINFEKSI Staphylococcus aureus
DOI:
https://doi.org/10.36387/jiis.v10i1.2263Keywords:
Starfruit leaf extract, Gel, Burns, Wound healing, Staphylococccus aureusAbstract
The World Health Organization (WHO) estimates that around 180,000 deaths occur due to burns. The healing process of burn wounds is influenced by several factors, such as the area, depth of the burn and infection. One of the bacteria that causes infection in burn wounds is Staphylococcus aureus. Starfruit leaf extract, used in gel form, is a natural remedy that offers benefits for burn treatment. This study aimed to analyze the effectiveness of starfruit leaf extract gel in healing burn wounds infected with Staphylococcus aureus in white rats. This research method was true experimental with a randomized posttest only control group design with 20 rats divided into four groups, namely the positive control group using bioplacenton (C1), the negative control group using gel base (C2), treatment group 1 with starfruit leaf extract gel with a concentration of 6% (P1) and group treatment 2 with starfruit leaf extract gel with a concentration of 12% (P2). The study found the smallest burn area on day 3 and day 7 was group C1 with an average of 2,799 cm2 and 2,324 cm2. On the 14th day it was group P2 with an average of 1,134 cm2. On the 21st day it was groups C1 and P2 with a mean of 0.163 cm2 and 0.164 cm2. The One-Way Anova test revealed significant differences in burn wound healing on days 3, 7, 14, and 21 (p < 0.05). Starfruit leaf extract gel effectively heals burns in white mice infected with S. aureus, with 12% concentration
References
Agung, I. G., & Hartini, A. (2023). Increasing the number of fibrolas in the healing of rat gingiva wounds with topically applied of leaves extracts of belimbing wuluh ( Averrhoa bilimbi Linn ) Peningkatan jumlah fibrolas pada penyembuhan luka gingiva tikus dengan pemberian ekstrak daun bel. Makassar Dental Journal, 422–425. https://doi.org/10.35856/mdj.v12i3.869
Ananta, G. P. (2020). Potensi Batang Pisang (Musa Pardisiaca L.) Dalam Penyembuhan Luka Bakar. Jurnal Ilmiah Kesehatan Sandi Husada, 11(1), 334–340. https://doi.org/10.35816/jiskh.v11i1.283 DOI: https://doi.org/10.35816/jiskh.v11i1.283
Ginting, S., Harnis, Z. E., Ilsanna, C., & Meliala, L. (2020). Perbandingan Efek Penyembuhan Luka Bakar Antara Gel Ekstrak Etanol Daun Afrika (Gymnanthemum amygdalinum Del.) Dengan Gel Ekstrak Etanol Daun Kelapa Sawit ( Elaeis guineensis Jacq.) Serta Kombinasinya Pada Kelinci Tahun 2019. Jurnal Penelitian Farmasi & Herbal, 3(1), 82–90. https://doi.org/10.36656/jpfh.v3i1.327 DOI: https://doi.org/10.36656/jpfh.v3i1.327
Harahap, S. R. Z. (2020). Uji Efektivitas Antibiotik Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.) dan Ekstrak Habatussauda (Nigella sativa L.) Terhadap Penyembuhan Luka Sayat Mencit Jantan (Mus musculus L.) yang Terinfeksi Staphylococcus aureus Secara In Vivo. 1–23. DOI: https://doi.org/10.30596/jph.v1i1.3874
Haris, A., Ayyasi, A. I., & Edsel, Y. A. (2018). Perbandingan Efektivitas Produk Lebah dan Salep Luka Bakar Terhadap Kecepatan Penyembuhan Luka Bakar Derajat II Pada Tikus Putih Jantan Galur Wistar. Jimki, 6(2), 63–71.
Hutabarat, R., & Deviana Ismail, D. (2022). Formulasi dan Uji Aktivitas Gel Ekstrak Etanol 96% Daun Belimbing Wuluh (Averrhoa bilmbi Linn) Terhadap Bakteri Staphylococcus epidermidis. Indonesia Natural Research Pharmaceutical Journal, 7(1), 32–43. DOI: https://doi.org/10.52447/inrpj.v7i1.5931
Kemenkes. (2019). Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07/Menkes/555/2019 Tentang Pedoman Nasional Pelayanan Kedokteran Tatalaksana Luka Bakar.
Markiewicz-Gospodarek, A., Kozioł, M., Tobiasz, M., Baj, J., Radzikowska-Büchner, E., & Przekora, A. (2022). Burn Wound Healing: Clinical Complications, Medical Care, Treatment, and Dressing Types: The Current State of Knowledge for Clinical Practice. International Journal of Environmental Research and Public Health, 19(3), 1338. https://doi.org/10.3390/ijerph19031338 DOI: https://doi.org/10.3390/ijerph19031338
Nadya, Meilina, R., Keusumawati, & Za, R. N. (2021). Aktivitas Penyembuhan Luka Salep Ekstrak Biji Ketumbar ( Coriandrum sativum L .) pada Mencit ( Mus musculus L .) yang Terinfeksi Staphylococcus Aureus Wound Healing Activity of Coriandrum sativum Extract Ointment in Mice Infected with Staphylococcus aureu. Journal of Healtcare Technology and Medicine, 7(2), 1662–1673.
Nugroho, R. A. (2018). Mengenal Mencit sebagai Hewan Laboratorium. Mulawarman University Press. Samarinda.
Riskesdas. (2018). Laporan Riset Kesehatan Dasar Provinsi Riau.
Rustian, E., Najwa, N., & Nurzillah, L. (2022). Efektivitas Gel Ekstrak Tangkai Talas ( Colocasia esculenta L . ) untuk Penyembuhan Luka Bakar pada Tikus Putih Jantan ( Eff ectivity Gel of Colocasia Esculenta ( L .) Stalk for the Burn Wound Healing in Male White Rats ). 20(1), 93–100. DOI: https://doi.org/10.35814/jifi.v20i1.1154
Sari, R. D. N., Budiawan, A., & Sumadji, A. R. (2023). Efektivitas Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.) Secara Topikal Terhadap Penyembuhan Luka Pada Kelinci (Oryctolagus cuniculus). Jurnal Ilmiah Manuntungt, 9(1), 64–70. https://doi.org/10.51352/jim.v9i1.660 DOI: https://doi.org/10.51352/jim.v9i1.660
Taufiq, & Ameilia, F. (2018). Formulasi dan Uji Mutu Fisik Sediaan Gel Ekstrak Etanol Herba Bandotan (Ageratum conyzoides L.). Jurnal Kesehatan Yamasi, 2(2), 1689–1699.
Tumigolung, D., Runtuwene, M., & Wewengkang, D. (2019). Efektifitas Penyembuhan Luka Bakar Salep Ekstrak Etanol Daun Soyogik (Sauraia Bracteosa DC) Pada Tikus Putih Jantan Galur Wistar (Rattus Norvegicus). PHARMACON, 8(2), 371. https://doi.org/10.35799/pha.8.2019.29303 DOI: https://doi.org/10.35799/pha.8.2019.29303
Ulupalu, F. F. M., Azizah, R. N., & Sukmawati. (2022). Potential Pegagan Leaves (Centella asiatica (L.)) as Burn Healer and Antibacterial against Staphylococcus aureus. Journal Microbiology Science, 2(2), 17–26. https://doi.org/10.56711/jms.v2i2.862 DOI: https://doi.org/10.56711/jms.v2i2.862
Utami, W., Saragih, E. B., Andini, M., & Sunarsih, E. S. (2023). Studi In Vivo Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi L.) Terhadap Penurunan Kadar Glukosa Darah Dan Penyembuhan Luka Pada Hewan Model Diabetes. Original Article MFF, 27(3), 88–92. https://doi.org/10.20956/mff.v27i3.28281
Wardani, I. G. A. A. K., Adrianta, ketut agus, & Megawati, F. (2018). Pengaruh Pemberian Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.) Terhadap Penyembuhan Luka Sayat Pada Mencit Jantan (Mus musculus L.). Jurnal Ilmiah Medicamento, 4(1), 40–43. DOI: https://doi.org/10.36733/medicamento.v4i1.881
WHO. (2023). Burns. World Health Organization.
Wijayanti, T. R. A., & Safitri, R. (2018). Uji Aktivitas Antibakteri Ekstrak Daun Belimbing Wuluh (Averrhoa Bilimbi Linn) Terhadap Pertumbuhan Bakteri Staphylococcus Aureus Penyebab Infeksi Nifas. Care : Jurnal Ilmiah Ilmu Kesehatan, 6(3), 277. https://doi.org/10.33366/cr.v6i3.999 DOI: https://doi.org/10.33366/cr.v6i3.999
Wintoko, R., & Yadika, A. D. N. (2020). Manajemen terkini perawatan luka. Jurnal Kedokteran Universitas Lampung, 4(2), 183–189.
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