OPTIMASI FORMULA HAIR TONIC MIKROEMULSI BIOTIN (VITAMIN B7) DENGAN METODE FACTORIAL DESIGN
DOI:
https://doi.org/10.36387/jiis.v8i1.1071Keywords:
Biotin, Optimization, Microemulsion gel, Factorial DesignAbstract
Loss becomes a problem in the hair that causes baldness. Biotin is a vitamin that nourishes hair and prevents hair loss. Biotin which is formulated in microemulsion tends to be transparent, has low viscosity and high solubility. Formula optimization was carried out to determine the concentration of span 80, tween 80, and PEG 400 in biotin microemulsion hair tonic. The research was conducted on an experimental basis using a factorial design method with 3 factors, namely span 80, tween 80, and PEG 400. The optimum microemulsion formula was determined using Design Expert 13 software using the Factorial Design method. Testing the physical quality of the preparation is carried out at the optimum formula. Optimization of biotin microemulsion hair tonic showed results of span 80 (20%), tween 80 (9.466%) and PEG 400 (5%) with a predicted viscosity of 46.75 cPs and globule size of 2.98 µm. Prediction testing and test results compared to the One Sample T-test showed results that were not significantly different with a significance value of >0.05. The optimum formula has a viscosity value of 47.67 cPs and a globule size of 2.4 µm. The results obtained concluded that the optimal composition composition of the biotin microemulsion formula from the combination of span 80, tween 80 and PEG 400 which produces hair tonic with good effects and physical quality is span 80 20%, tween 80 9.47% and PEG 400 5%.
References
Arifin, A., Intan, & Ida, N. (2022). Formulasi Dan Uji Stabilitas Fisik Gel Antijerawat Ekstrak Etanol Daun Suruhan (Peperomia Pellucida L.). Jurnal Ilmiah Ibnu Sina (Jiis): Ilmu Farmasi Dan Kesehatan, 7(2), 280–289.
Ariviani, S., Raharjo, S., Anggrahini, S. & Naruki, S. 2015. Formulasi Dan Stabilitas Mikroemulsi O/W Dengan Metode Emulsifikasi Spontan Menggunakan VCO Dan Minyak Sawit Sebagai Fase Minyak: Pengaruh Rasio Surfaktan-Minyak. Jurnal Agritech, 35(01): 27.
Fitriani, E.W., Imelda, E., Kornelis, C. & Avanti, C. 2016. Karakterisasi dan Stabilitas Fisik Mikroemulsi Tipe A/M Dengan Berbagai Fase Minyak. Pharmaceutical Sciences and Research, 3(1): 31–44.
Handayani, R. & Kautsar, A.P. 2018. Strategi Baru Sistem Penghantaran Obat Transdermal Menggunakan Peningkat Penetrasi Kimia. Farmaka, 15(3): 24– 36
Hidayah, R.N., Gozali, D., Hendriani, R. & Mustarichie, R. 2020. Formulasi dan Evaluasi Sediaan Herbal Hair tonic sebagai Perangsang Pertumbuhan Rambut. Majalah Farmasetika, 5(5): 218–232.
Meynda, K. & Angraini, D. 2017. Suplementasi Biotin untuk Perawatan Pasien dengan Alopesia. Medula, 7(5): 160–164.
Nabillah, S., Noval, & Hidayah, N. (2022). Formulasi Dan Evaluasi Nano Hidrogel Ekstrak Daun Serunai (Chromolaena Odorata L.) Dengan Variasi Konsentrasi Polimer Carbopol 980. Jurnal Ilmiah Ibnu Sina (Jiis): Ilmu Farmasi Dan Kesehatan, 7(2), 340–349.
Novrianti, I., Wijayanti, S., & Heriani, H. (2021). Uji Efektifitas Sediaan Spray Gel Ekstrak Bunga Kenop (Gomphrena Globosa L) Terhadap Penyembuhan Luka Bakar. Jurnal Ilmiah Ibnu Sina (Jiis): Ilmu Farmasi Dan Kesehatan, 6(2), 46–55.
Ramadhani, R.A., Riyadi, D.H.S., Triwibowo, B. & Kusumaningtyas, R.D. 2017. Review Pemanfaatan Design Expert untuk Optimasi Komposisi Campuran Minyak Nabati sebagai Bahan Baku Sintesis Biodiesel. Jurnal Teknik Kimia dan Lingkungan, 1((1)): 11–16.
Roohinejad, S., Oey, I., Everett, D.W. & Greiner, R. 2018. Microemulsions. In Emulsion-based Systems for Delivery of Food Active Compounds: Formation, Application, Health and Safety. 231–262.
Sholichah Rohmanii, & Putri, T. R. (2022). Formulasi Anti-Aging Cream Potassium Azeloyl Diglycinate Terhadap Stabilitas Fisika-Kimia Krim Dengan Variasi Konsentrasi Trietanolamin Sebagai Emulgator. Jurnal Ilmiah Ibnu Sina (Jiis): Ilmu Farmasi Dan Kesehatan. 7(2), 310–319.
Suhery, W.N., Febrina, M. & Permatasari, I. 2018. Microemulsion Formulation of Combination of Virgin Coconut Oil and Rice Bran Oil for Hair Growth. Traditional Medicine Journal, 23(1): 40–46
Sulastri, E., Oktaviani, C. & Yusriadi. 2015. Formulasi Mikroemulsi Ekstrak Bawang Hutan dan Uji Aktivitas Antioksidan. Jurnal Pharmascience Research Article, 2(No. 2 Oktober): 1–14.
Wikantyasning, E.R., Indianie, N., 2021. Optimisasi Tween 80 dan Span 80 sebagai Emulgator dalam Formula Krim Tabir Surya Kombinasi Ekstrak Etanol Daun Alpukat (Persea americana M.) dan Nanopartikel Seng Oksida dengan Metode Simplex Lattice Design. CERATA Jurnal Ilmu Farmasi, 12(1), 1–28
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