UJI EFEKTIVITAS DAN KEAMANAN KOMBINASI METFORMIN-VILDAGLIPTIN PADA DIABETES MELITUS TIPE 2 DI RSPAL Dr. RAMELAN SURABAYA

Authors

  • Dwi Octamy Sari RSPAL Dr Ramelan
  • Amelia Lorensia Fakultas Farmasi, Universitas Surabaya
  • Abdul Rahem Fakultas Farmasi, Universitas Airlangga
  • Lestiono Lestiono RSPAL Dr Ramelan Surabaya

DOI:

https://doi.org/10.36387/jiis.v8i2.1309

Keywords:

DM type 2, Metformin, Vildagliptin

Abstract

       Metformin is the first-line therapy for Diabetes Mellitus (DM), which has not been able to control blood glucose in type 2 DM. One of the Dipeptidyl Peptidase IV Inhibitor (DPP4-I) groups, namely vildagliptin, has been included in the National Formulary which is used as a combination for the therapy of DM patients Type 2. Research objectives to know the effectiveness and safety of the combination of metformin-vildagliptin in type 2 DM at RSPAL Dr. Ramelan Surabaya. This research method uses a quantitative method with an observational study design, with retrospective data collection based on the Medical Records of Type 2 DM patients who first received metformin-vildagliptin combination therapy (n = 30) carried out observations, and recorded the results of Fasting Blood Glucose (GDP) examinations, Postprandial 2-hour blood glucose (GD2JPP), and HbA1C at baseline and after 3 months of therapy, and observed the safety of the combination. Results The metformin-vildagliptin combination reduced GDP 33.13 ± 40.73 mg/dL, GD2JPP 34.30 ± 48.81 mg/dL, and HbA1C 0.89 ± 0.86%. Did not show any side effects of hypoglycemia, but 3.33% experienced nausea/vomiting and dyspepsia. It was concluded that the combination of metformin-vildagliptin was able to reduce GDP, GD2JPP, and HbA1C,

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Published

2023-10-31

How to Cite

Sari, D. O., Lorensia, A., Rahem, A., & Lestiono, L. (2023). UJI EFEKTIVITAS DAN KEAMANAN KOMBINASI METFORMIN-VILDAGLIPTIN PADA DIABETES MELITUS TIPE 2 DI RSPAL Dr. RAMELAN SURABAYA. Jurnal Ilmiah Ibnu Sina, 8(2), 166–175. https://doi.org/10.36387/jiis.v8i2.1309

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