FORMULASI FILM FORMING SPRAY DARI KLORAMFENIKOL UNTUK LUKA

Authors

  • Rusdiati Helmidanora Sekolah Tinggi Ilmu Kesehatan Samarinda
  • Siti Jubaidah Sekolah Tinggi Ilmu Kesehatan Samarinda
  • Is alukal Fauziah A.A Sekolah Tinggi Ilmu Kesehatan Samarinda

DOI:

https://doi.org/10.36387/jiis.v8i2.1517

Keywords:

Topical, Spray Film Forming System, Chloramfenicol, Transdermal

Abstract

The wound healing process should be short so as not to interfere with productivity and reduce costs. SFFS (spray film forming system) is a combination of transdermal preparations in which a polymer solution is sprayed onto the skin and will form an almost transparent film by evaporation of the solvent. Film-forming solutions are particularly advantageous for transporting the active substance to the site of action by the shortest route in cases of dermal or lower tissue infections. Chloramphenicol is a lipophilic drug so it penetrates the skin well because the stratum corneum matrix is ​​also lipophilic. The purpose of this study was to make a formulation of a sprayed chloramphenicol film-forming solution in order to obtain the best formula and increase effectiveness. The research was carried out on an experimental basis and three formulas were prepared with different polymer concentrations. The results of the study obtained a film-forming spray for each formula with a film formed that was flexible and adhered well to the skin, with a pH of 6. The time needed to make the film layer in skin is 0.87-1.19 minutes with an average dose weight of spray is 61.33-85.33 mg.

References

Alberti, I., Grenier, A., Kraus, H., & Carrara, D. N. (2005). Pharmaceutical development and clinical effectiveness of a novel gel technology for transdermal drug delivery. Http://Dx.Doi.Org/10.1517/17425247.2.5.935, 2(5), 935–950. https://doi.org/10.1517/17425247.2.5.935

Bakhrushina, E. O., Shumkova, M. M., Sergienko, F. S., Novozhilova, E. V., & Demina, N. B. (2023). Spray Film-Forming systems as promising topical in situ Systems: A review. Saudi Pharmaceutical Journal, 31(1), 154–169. https://doi.org/10.1016/J.JSPS.2022.11.014

Bakkiyaraj, D., Sritharadol, R., Padmavathi, A. R., Nakpheng, T., & Srichana, T. (2017). Anti-biofilm properties of a mupirocin spray formulation against Escherichia coli wound infections. Http://Dx.Doi.Org/10.1080/08927014.2017.1337100, 33(7), 591–600. https://doi.org/10.1080/08927014.2017.1337100

Chavan, P., Bajaj, A., & Parab, A. (2016). Topical Sprays: Novel Drug Delivery System. International Journal of Pharma And Chemical Research, 2(2), 102–111. www.ijpacr.com

Deshmukh, S. N., Gade, V., Garud, A., Dumbre, R., Maharaj, S., Girme, S., & Shewalkar, S. (2022). Novel Film Forming Spray from Tea Tree Leaves with Special Emphasis on Development , Formulation and Evaluation. 6(5), 5179–5184.

Gngr, S., Sedef, M., & zsoy, Y. (2012). Plasticizers in Transdermal Drug Delivery Systems. Recent Advances in Plasticizers. https://doi.org/10.5772/38156

Karki, S., Kim, H., Na, S. J., Shin, D., Jo, K., & Lee, J. (2016). Thin films as an emerging platform for drug delivery. In Asian Journal of Pharmaceutical Sciences (Vol. 11, Issue 5, pp. 559–574). Shenyang Pharmaceutical University. https://doi.org/10.1016/j.ajps.2016.05.004

Kathe, K., & Kathpalia, H. (2017). Film forming systems for topical and transdermal drug delivery. Asian Journal of Pharmaceutical Sciences, 12(6), 487–497. https://doi.org/10.1016/J.AJPS.2017.07.004

Lukić, M., Pantelić, I., & Savić, S. D. (2021). Towards optimal ph of the skin and topical formulations: From the current state of the art to tailored products. In Cosmetics (Vol. 8, Issue 3). MDPI AG. https://doi.org/10.3390/cosmetics8030069

Menon, G. K., Cleary, G. W., & Lane, M. E. (2012). The structure and function of the stratum corneum. International Journal of Pharmaceutics, 435(1), 3–9. https://doi.org/10.1016/J.IJPHARM.2012.06.005

Mohammadi, Z., & Abbott, P. V. (2015). Local applications of antibiotics and antibiotic-based agents in endodontics. Endodontic Irrigation: Chemical disinfection of the root canal system. 253–266.

Okunye, O. L., Idowu, P. A., & Makinde, O. S. (2020). EVALUATION OF SOME COMMERCIAL ANTIMICROBIAL OINTMENTS ON SELECTED BACTERIAL AND FUNGAL STRAINS OF CLINICAL IMPORTANCE. Annals of Ibadan Postgraduate Medicine, 18(1), 44. /pmc/articles/PMC7893297/

Paradkar, M., Thakkar, V., Soni, T., Gandhi, T., & Gohel, M. (2015). Formulation and evaluation of clotrimazole transdermal spray. Https://Doi.Org/10.3109/03639045.2014.1002408, 41(10), 1718–1725. https://doi.org/10.3109/03639045.2014.1002408

Pünnel, L. C., & Lunter, D. J. (2021). Film-forming systems for dermal drug delivery. Pharmaceutics, 13(7). https://doi.org/10.3390/pharmaceutics13070932

Shokrollahi, H. (2016). The effect of the volume fraction and viscosity on the compression and tension behavior of the cobalt-ferrite magneto-rheological fluids. Engineering Science and Technology, an International Journal, 19(1), 604–609. https://doi.org/10.1016/j.jestch.2015.09.011

Umar, A. K., Butarbutar, M., Sriwidodo, S., & Wathoni, N. (2020). Film-Forming Sprays for Topical Drug Delivery. Drug Design, Development and Therapy, 14, 2909. https://doi.org/10.2147/DDDT.S256666

Wintoko, R., Dwi, A., Yadika, N., Terkini, M., & Luka, P. (2020). Manajemen Terkini Perawatan Luka. Jurnal Kedokteran Universitas Lampung, 4(2), 183–189. https://juke.kedokteran.unila.ac.id/index.php/JK/article/view/2893

Published

2023-10-31

How to Cite

Helmidanora, R., Jubaidah, S., & Fauziah A.A, I. alukal. (2023). FORMULASI FILM FORMING SPRAY DARI KLORAMFENIKOL UNTUK LUKA. Jurnal Ilmiah Ibnu Sina, 8(2), 327–337. https://doi.org/10.36387/jiis.v8i2.1517

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