POTENSI ANTIATEROGENIK KOMBINASI EKSTRAK ETANOL RIMPANG KUNYIT DAN DAUN PEGAGAN DALAM MENURUNKAN RISIKO PENYAKIT KARDIOVASKULAR PADA MODEL HEWAN TIKUS OBES
DOI:
https://doi.org/10.36387/jiis.v11i1.2882Keywords:
Atherosclerosis, Turmeric, Gotu kola, Lipid profile, AIP, Anti-atherogenicAbstract
Obesity is a major risk factor for atherosclerosis and cardiovascular disease, characterized by dyslipidemia and oxidative stress. This study aimed to evaluate the anti-atherogenic effects of a combination of ethanol extracts of turmeric rhizome (Curcuma longa) and gotu kola leaves (Centella asiatica) in obese–hyperlipidemic rats. Male rats were divided into seven groups: normal, induction, comparator (orlistat 10.8 mg/kgBW), and treatment groups receiving single and combined extracts (ERK, EDP, ERKDP 200:100, ERKDP 100:200 mg/kgBW). Obesity and hyperlipidemia were induced using a high-fat and fructose diet for 60 days. Parameters measured included body weight, lipid profile (TG, HDL, LDL, total cholesterol), Atherogenic Index of Plasma (AIP), and aortic histology. The induction group showed significant increases in body weight, triglycerides, LDL, and AIP (P<0.05). All treatment groups significantly improved lipid profiles and reduced AIP compared to the induction group. The ERKDP 100:200 mg/kgBW combination showed the most optimal effect, with a 51.83% reduction in LDL, a 54.60% decrease in AIP, and a 146% increase in HDL. Histological analysis also demonstrated reduced foam cell formation and improved aortic structure in this group. In conclusion, the combination of turmeric and gotu kola extracts, particularly at a dose of 100:200 mg/kgBW, exhibits significant anti-atherogenic potential through lipid profile improvement, AIP reduction, and vascular protection.
References
Ahmad, A. (2023). Pengaruh pemberian dangke terhadap kadar glukosa dan profil lipid tikus yang diinduksi diet tinggi lemak dan fruktosa.
Dipiro, J. T., Yee, G., & Ellingrod, V. (2020). Pharmacotherapy: A pathophysiologic approach (3rd ed.). McGraw Hill.
Durham, A. L., et al. (2021). Vascular smooth muscle cell phenotypic switching. Nature Reviews Cardiology, 18, 482–498.
Farizal, J., Marlina, L., & Halimatussa’diah. (2019). Hubungan kadar trigliserida dengan mahasiswa obesitas. Jurnal Ilmiah AVICENNA, 14(2), 1–51.
Hall, M. E., Cohen, J. B., Ard, J. D., Egan, B. M., Hall, J. E., Lavie, C. J., ... & American Heart Association Council. (2021). Weight-loss strategies for prevention and treatment of hypertension. Hypertension, 5, e38–e50.
Handayani, V. (2022). Tumbuhan berpotensi obat Desa Sanrobone Kabupaten Takalar.
Harwood, H. J. (2012). The adipocyte as an endocrine organ in the regulation of metabolic homeostasis. Neuropharmacology, 63(1), 57–75.
Hasimun, P., Azhary, D. P., & Saputro, M. R. (2024). Formulasi dan evaluasi permen jelly dari ekstrak daun pegagan dan rimpang kunyit untuk kesehatan kardiovaskular. An-Najat, 2(2), 1–12.
Islam, M. S., Wei, P., Suzauddula, M., Nime, I., Feroz, F., Acharjee, M., & Pan, F. (2024). The interplay of factors in metabolic syndrome: Understanding its roots and complexity. Molecular Medicine, 30(1), 279.
Leopold, J. A. (2020). Antioxidants and atherosclerosis. Journal of the American College of Cardiology, 75(21), 2765–2784.
Libby, P. (2021). The changing landscape of atherosclerosis. Nature, 592(7855), 524–533.
Mahakam, H., Nurfazri, A., & Safitri, S. (2023). Aktivitas antidislipidemia ekstrak etanol herba pegagan pada tikus Wistar jantan obesitas. Jurnal Ilmiah Ibnu Sina, 2, 155–165.
Niroumand, S., et al. (2015). Atherogenic index of plasma (AIP): A marker of cardiovascular disease. Medical Journal of the Islamic Republic of Iran, 29(1), 627–635.
Ouyang, X., & Liu, Z. (2024). Regulatory T cells and macrophages in atherosclerosis. Frontiers in Immunology, 15, 1435021.
Pahwa, R., Singh, A., Adams-Huet, B., Devaraj, S., & Jialal, I. (2021). Increased inflammasome activity in subcutaneous adipose tissue of patients with metabolic syndrome. Diabetes/Metabolism Research and Reviews, 37(3), e3383.
Putri, M. A., Alioes, Y., & Rusjdi, S. R. (2021). Hubungan derajat obesitas dengan kadar LDL pada mahasiswa Fakultas Kedokteran Universitas Andalas. Jurnal Ilmu Kesehatan Indonesia, 2(2), 42–50.
Rameshreddy, P., et al. (2018). Obesity-alleviating potential of asiatic acid. Molecular and Cellular Biochemistry, 442(1–2), 143–154.
Speakman, J. R., et al. (2022). Animal models of obesity: utility and limitations. Disease Models & Mechanisms, 15(3), dmm049913.
Zhang, X., Li, Y., Wang, J., Chen, H., & Liu, Q. (2022). Effects of antioxidant supplementation on LDL oxidation and macrophage infiltration. Journal of Nutritional Biochemistry, 109, 109123.
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