PREVALENSI DAN POLA SENSITIVITAS Klebsiella pneumoniae DAN Escherichia coli PENGHASIL EXTENDED SPECTRUM BETALAKTAMASE DI RSPAD GATOT SOEBROTO TAHUN 2021
DOI:
https://doi.org/10.36387/jiis.v9i2.1670Keywords:
ESBL , Escherichia coli, Klebsiella pneumonae, Sensitivity patternAbstract
ESBL-producing K. pneumoniae and E. coli are the Enterobacteriaceae that most commonly cause bacteriemia and nosocomial infections in the world. It is important to be aware of these bacteria to prevent an increase in infections with these resistant bacteria in hospitals. This research is a retrospective descriptive study, aiming to determine the prevalence of ESBL produced by K. Pneumoniae and E. coli and their sensitivity patterns. The data comes from clinical specimens that were examined for bacterial culture and antibiotic sensitivity tests in the Clinical Pathology Microbiology Lab in 2021. ESBL test using VITEK 2 compact tool. The results of the research were that E. coli was the most ESBL producing bacteria (50.9%) while K. pneumoniae was 20.9%. The highest prevalence of positive ESBL came from the ICU (41.4%) and the surgical ward (40.8%). Almost all rooms from which specimens were sent had a higher prevalence of positive ESBL E.coli, while for K.pneumoniae negative ESBL was higher. The most common types of positive specimens were bronchial lavage (67.4%) and wound swab (47.1%). Antibiotics that have high sensitivity to ESBL positive bacteria are Amikacin, Tigecycline and Meropenem.This research shows an increase in the prevalence of ESBL-producing K. pneumoniae and E. coli at the Gatot Soebroto Army Hospital, although it is still lower than several other national referral hospitals. Infection control, rational use of antimicrobials and prevention of transmission must continue to be pursued to reduce its prevalence.
References
Anggraini, D., Sholihin, U. H., Savira, M., Djojosugito, F. A., Irawan, D., & Rustam, R. P. (2018). Prevalensi dan Pola Sensitivitas Enterobacteriaceae Penghasil ESBL di RSUD Arifin Achmad Pekanbaru. Jurnal Kedokteran Brawijaya, 30(1), 47. https://doi.org/10.21776/ub.jkb.2018.030.01.9
Baldwin, C. M., Lyseng-Williamson, K. A., & Keam, S. J. (2008). ADIS DRUG EVALUATION Meropenem A Review of its Use in the Treatment of Serious Bacterial Infections. In Drugs (Vol. 68, Issue 6).
Desrini, S. (n.d.). View of Resistensi Antibiotik, Akankah Dapat Dikendalikan ?
Hadi, U., Kuntaman, K., Qiptiyah, M., & Paraton, H. (2013). Problem of Antibiotic Use and Antimicrobial Resistance in Indonesia: Are We Really Making Progress? Indonesian Journal of Tropical and Infectious Disease, 4(4), 5. https://doi.org/10.20473/ijtid.v4i4.222
Husna, A., Rahman, M. M., Badruzzaman, A. T. M., Sikder, M. H., Islam, M. R., Rahman, M. T., Alam, J., & Ashour, H. M. (2023). Extended-Spectrum β-Lactamases (ESBL): Challenges and Opportunities. In Biomedicines (Vol. 11, Issue 11). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/biomedicines11112937
Kemenkes, R. (2021). Pedoman Penggunaan Antibiotik. Pedoman Penggunaan Antibiotik, 1–97.
Kuntaman, Karuniawati, A., Gunardi, W., Anggaini, D., Santosaningsih, D., & et, al. (2022). Surveilans Resistansi Antibiotik Rumah Sakit di Indonesia Tahun 2021. 1–98.
Machado, E., Costa, P., & Carvalho, A. (2022). Occurrence of Healthcare-Associated Infections (HAIs) by Escherichia coli and Klebsiella spp. Producing Extended-Spectrum β-lactamases (ESBL) and/or Carbapenemases in Portuguese Long-Term Care Facilities. Pathogens, 11(9). https://doi.org/10.3390/pathogens11091019
Muztika, S. A. dan P. S. A. K., Extended, pneumoniae dan E. coli P., Padang, S. B. L. di R. D. M. D., Nasrul, E., & Alia, E. (2020). Prevalensi Dan Pola Sensitivitas Antibiotik Klebsiella Pneumoniae Dan Escherichia Coli Penghasil Extended Spectrum Beta Laktamase Di Rsup Dr. M. Djamil Padang Suci. Jurnal Kesehatan Andalas, 9(2), 189. Https://Doi.Org/10.25077/Jka.V9i2.1272
Purwaningrum, N. D., Murtisiwi, L., & Pratimasari, D. (2022). Uji Aktivitas Antibakteri Ekstrak Dan Fraksi N-Heksan, Etil Asetat Dan Air Dari Sabut Kelapa Muda (Cocos Nucifera Linn) Terhadap Escherichia Coli Esbl (Extended Spectrum Beta Lactamase). Jurnal Ilmiah Ibnu Sina (Jiis): Ilmu Farmasi Dan Kesehatan, 7(1), 29–37. Https://Doi.Org/10.36387/Jiis.V7i1.773
Rawat, D., & Nair, D. (2010). Extended-Spectrum ß-Lactamases In Gram Negative Bacteria. Journal Of Global Infectious Diseases, 2(3), 263. Https://Doi.Org/10.4103/0974-777x.68531
Shah, A. A., Hasan, F., Ahmed, S., & Hameed, A. (2004). Characteristics, Epidemiology And Clinical Importance Of emerging strains of Gram-negative bacilli producing extended-spectrum β-lactamases. In Research in Microbiology (Vol. 155, Issue 6, pp. 409–421). https://doi.org/10.1016/j.resmic.2004.02.009
Siahaan, S., Herman, M. J., & Fitri, N. (2022). Antimicrobial Resistance Situation in Indonesia: A Challenge of Multisector and Global Coordination. Journal of Tropical Medicine, 2022. https://doi.org/10.1155/2022/2783300
Singh, N., Pattnaik, D., Neogi, D. K., Jena, J., & Mallick, B. (2016). Prevalence of ESBL in escherichia coli isolates among ICU patients in a tertiary care hospital. Journal of Clinical and Diagnostic Research, 10(9), DC19–DC22. https://doi.org/10.7860/JCDR/2016/21260.8544
Sunarno, S., Puspandari, N., Fitriana, F., Nikmah, U. A., Idrus, H. H., & Panjaitan, N. S. D. (2023). Extended spectrum beta lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae in Indonesia and South East Asian countries: GLASS Data 2018. AIMS Microbiology, 9(2), 218–227. https://doi.org/10.3934/microbiol.2023013
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